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Chemical Compound Review

NG-nitroarginine     (2S)-2-amino-5-[(amino- nitramido...

Synonyms: NOLA, L-NOARG, L-NNA, AmbotzHAA5800, Tocris-0664, ...
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Disease relevance of Ngamma-Nitro-L-arginine


Psychiatry related information on Ngamma-Nitro-L-arginine


High impact information on Ngamma-Nitro-L-arginine

  • In vitro experiments indicated that NO synthase (NOS) inhibition by N-nitro-L-arginine methyl ester (L-NAME) enhanced IFN-gamma and TNF production by splenocytes in response to SEB [11].
  • To determine the role of eNOS in mediating these effects, mice were treated with N-nitro-L-arginine methyl ester (L-NAME) [12].
  • Immediately after birth, at 140 d of gestation, during the 3-h study period, mean pulmonary arterial pressure did not decrease in N omega-nitro-L-arginine-treated lambs; the increase in pulmonary blood flow and decrease in pulmonary vascular resistance were markedly attenuated compared to saline-treated lambs [13].
  • Moreover, when the endogenous constitutive levels of NO made by endothelial cells are suppressed using N-omega-nitro-L-arginine, a potent competitive inhibitor of NO synthase, the baseline levels of ET-1 produced in normoxic environments are increased three- to fourfold [14].
  • Nitric oxide synthesis by IL-1-activated smooth muscle cells is inhibited by NAA, NMA, and N omega-nitro-L-arginine (NNA) with ED50 (i.e., effective dose for 50% inhibition) values of 20, 60, and 1000 microM, respectively; this rank order of inhibition is characteristic of an agonist-unregulated, inducible isoform of nitric oxide synthase [15].

Chemical compound and disease context of Ngamma-Nitro-L-arginine


Biological context of Ngamma-Nitro-L-arginine


Anatomical context of Ngamma-Nitro-L-arginine


Associations of Ngamma-Nitro-L-arginine with other chemical compounds


Gene context of Ngamma-Nitro-L-arginine

  • We found that the NO synthase inhibitor N-nitro-l-arginine methyl ester could reverse the inhibitory effects of VEGF on lymphocyte adhesion and EC cytoskeleton rearrangement [34].
  • METHODS: We assessed: (1) effect of preconditioning on F16BP content; (2) effect of NO on GAPDH activity before and during sustained ischaemia; and (3) protective effect of F16BP in control, ischaemic, and preconditioned animals with or without administration of N-nitro-L-arginine methyl ester (L-NAME), NO donor, or F16BP [35].
  • On day 6, mice were randomized to receive (a) PBS (control), (b) DC101 [VEGF receptor 2 (VEGFR-2) antibody] by i.p. injection, (c) N-nitro-l-arginine (NNLA; NOS inhibitor) in the drinking water, or (d) both DC101 and NNLA [36].
  • The iNOS inhibitor N omega-nitro-L-arginine methyl ester increased B. suis multiplication specifically in IFN-gamma-treated cells infected with ops-Brucella, demonstrating a microbicidal effect of the NO produced [37].
  • Oral administration of N omega-nitro-L-arginine methyl (from day 4 postinfection) increased mortality rates in both IL-5-/- and WT mice, indicating a protective role for nitric oxide during the early stages of oral T. gondii infection [38].

Analytical, diagnostic and therapeutic context of Ngamma-Nitro-L-arginine

  • RESULTS: Electrical stimulation on the LES evoked inhibitory junction potentials (IJPs), which were reduced by 60% by 100 micromol/L N-nitro-L-arginine and subsequently blocked by 0.5 micromol/L apamin, unmasking excitatory junction potentials, which were abolished by 1 micromol/L hyoscine [39].
  • METHODS AND RESULTS: Coronary vasomotor response was studied in pigs before and after chronic oral administration of the NO synthesis antagonist N omega-nitro-L-arginine methyl ester (L-NAME) 30 for 2 weeks [40].
  • Partial portal vein-ligated or sham-operated rats were pretreated with a continuous intravenous infusion of either N omega-nitro-L-arginine (50 or saline [32].
  • For 2 days before partial portal vein ligation or sham operation and then continuously for 4 days after the operation, animals received either placebo (0.9% saline) or N omega-nitro-L-arginine (approximately 2 micrograms/kg/min) intravenously through a subcutaneously implanted Alzet osmotic pump (model 2ML1; Alza, Palo Alto, CA) [4].
  • Radiocontrast-induced nephropathy was produced in anesthetized rats (N = 6/group) by intravenous injection of indomethacin (5.0 mg/kg), the nitric oxide synthesis inhibitor N-nitro-L-arginine methyl ester (10.0 mg/kg), vehicle or antagonist, and the radiocontrast agent lopamidol (2,9 g iodine/kg) [41].


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  18. Mechanisms of estrogen-induced vasodilation: in vivo studies in canine coronary conductance and resistance arteries. Sudhir, K., Chou, T.M., Mullen, W.L., Hausmann, D., Collins, P., Yock, P.G., Chatterjee, K. J. Am. Coll. Cardiol. (1995) [Pubmed]
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  20. Molecular mechanisms of cannabinoid protection from neuronal excitotoxicity. Kim, S.H., Won, S.J., Mao, X.O., Jin, K., Greenberg, D.A. Mol. Pharmacol. (2006) [Pubmed]
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  28. Nitric oxide mediates the increase in local cerebral blood flow during focal seizures. Pereira de Vasconcelos, A., Baldwin, R.A., Wasterlain, C.G. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  29. Potentiation of osteoclast bone-resorption activity by inhibition of nitric oxide synthase. Kasten, T.P., Collin-Osdoby, P., Patel, N., Osdoby, P., Krukowski, M., Misko, T.P., Settle, S.L., Currie, M.G., Nickols, G.A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
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  34. Effects of vascular endothelial growth factor on the lymphocyte-endothelium interactions: identification of caveolin-1 and nitric oxide as control points of endothelial cell anergy. Bouzin, C., Brouet, A., De Vriese, J., Dewever, J., Feron, O. J. Immunol. (2007) [Pubmed]
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  36. Roles of nitric oxide synthase inhibition and vascular endothelial growth factor receptor-2 inhibition on vascular morphology and function in an in vivo model of pancreatic cancer. Camp, E.R., Yang, A., Liu, W., Fan, F., Somcio, R., Hicklin, D.J., Ellis, L.M. Clin. Cancer Res. (2006) [Pubmed]
  37. Expression and bactericidal activity of nitric oxide synthase in Brucella suis-infected murine macrophages. Gross, A., Spiesser, S., Terraza, A., Rouot, B., Caron, E., Dornand, J. Infect. Immun. (1998) [Pubmed]
  38. Counter-protective role for interleukin-5 during acute Toxoplasma gondii infection. Nickdel, M.B., Roberts, F., Brombacher, F., Alexander, J., Roberts, C.W. Infect. Immun. (2001) [Pubmed]
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