- WR-1065, the active metabolite of amifostine (Ethyol), does not inhibit the cytotoxic effects of a broad range of standard anticancer drugs against human ovarian and breast cancer cells. Alberts, D.S., Speicher, L.A., Krutzsch, M., Wymer, J., Capizzi, R.L., Conlon, J., Barrett, A., Aickin, M. Eur. J. Cancer (1996)