Chemical Compound Review:
AG-F-03179 2-(3- aminopropylamino)ethanethiol
Synonyms:
CHEBI:72583, NSC-647527, AC1L2XJB, AC1Q7GQD, LS-65769, ...
- Further evidence that the radioprotective aminothiol, WR-1065, catalytically inactivates mammalian topoisomerase II. Snyder, R.D., Grdina, D.J. Cancer Res. (2000)
- Activation of the nuclear transcription factor kappaB (NFkappaB) and differential gene expression in U87 glioma cells after exposure to the cytoprotector amifostine. Kataoka, Y., Murley, J.S., Khodarev, N.N., Weichselbaum, R.R., Grdina, D.J. Int. J. Radiat. Oncol. Biol. Phys. (2002)
- WR-1065, the active metabolite of amifostine (Ethyol), does not inhibit the cytotoxic effects of a broad range of standard anticancer drugs against human ovarian and breast cancer cells. Alberts, D.S., Speicher, L.A., Krutzsch, M., Wymer, J., Capizzi, R.L., Conlon, J., Barrett, A., Aickin, M. Eur. J. Cancer (1996)
- Relationships between DNA damage and the survival of radiosensitive mutant Chinese hamster cell lines exposed to gamma-radiation: Part 2. Effect of cellular redox status. Murray, D., Prager, A., Meyn, R.E., Davison, S., Green, A.D. Int. J. Radiat. Biol. (1993)
- Protection of human tumor cells of differing radiosensitivity by WR-1065. Murray, D., Rosenberg, E., Allalunis-Turner, M.J. Radiat. Res. (2000)
- Phase III randomized trial of amifostine as a radioprotector in head and neck cancer. Brizel, D.M., Wasserman, T.H., Henke, M., Strnad, V., Rudat, V., Monnier, A., Eschwege, F., Zhang, J., Russell, L., Oster, W., Sauer, R. J. Clin. Oncol. (2000)
- Uptake of WR-2721 derivatives by cells in culture: identification of the transported form of the drug. Calabro-Jones, P.M., Aguilera, J.A., Ward, J.F., Smoluk, G.D., Fahey, R.C. Cancer Res. (1988)
- N-(2-mercaptoethyl)-1,3-propanediamine (WR-1065) protects thymocytes from programmed cell death. Ramakrishnan, N., Catravas, G.N. J. Immunol. (1992)
- Delayed cytoprotection after enhancement of Sod2 (MnSOD) gene expression in SA-NH mouse sarcoma cells exposed to WR-1065, the active metabolite of amifostine. Murley, J.S., Kataoka, Y., Weydert, C.J., Oberley, L.W., Grdina, D.J. Radiat. Res. (2002)
- Opposite effects of WR-2721 and WR-1065 on radiation-induced hypothermia: possible correlation with oxygen uptake. Kandasamy, S.B., Kumar, K.S., Hunt, W.A., Weiss, J.F. Radiat. Res. (1988)
- Mechanisms for the oxygen radical-mediated toxicity of various thiol-containing compounds in cultured mammalian cells. Held, K.D., Biaglow, J.E. Radiat. Res. (1994)
- Hypotensive mechanisms of amifostine. Ryan, S.V., Carrithers, S.L., Parkinson, S.J., Skurk, C., Nuss, C., Pooler, P.M., Owen, C.S., Lefer, A.M., Waldman, S.A. Journal of clinical pharmacology. (1996)
- Radiation protection by alpha-methyl-homocysteine thiolactone in vitro. Koch, K.E., Roberts, J.C., Lubec, G. Life Sci. (1997)
- Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-cytotoxic and anti-mutagenic mechanisms of action. Grdina, D.J., Shigematsu, N., Dale, P., Newton, G.L., Aguilera, J.A., Fahey, R.C. Carcinogenesis (1995)
- The effects of cycloheximide and WR-1065 on radiation-induced repair processes: a mechanism for chemoprevention. Murley, J.S., Grdina, D.J. Carcinogenesis (1995)
- Hprt mutations in human T-lymphocytes reflect radioprotective effects of the aminothiol, WR-1065. Clark, L.S., Albertini, R.J., Nicklas, J.A. Carcinogenesis (1996)
- Tissue levels of WR-1065, the active metabolite of amifostine (Ethyol), are equivalent following intravenous or subcutaneous administration in cynomolgus monkeys. Bachy, C.M., Fazenbaker, C.A., Kifle, G., McCarthy, M.P., Cassatt, D.R. Oncology (2004)
- Effects of dose and schedule on the efficacy of ethyol: preclinical studies. Cassatt, D.R., Fazenbaker, C.A., Kifle, G., Bachy, C.M. Semin. Oncol. (2003)
- Inhibition of spontaneous metastases formation by amifostine. Grdina, D.J., Kataoka, Y., Murley, J.S., Hunter, N., Weichselbaum, R.R., Milas, L. Int. J. Cancer (2002)
- Interaction of amifostine and ionizing radiation on transcriptional patterns of apoptotic genes expressed in human microvascular endothelial cells (HMEC). Khodarev, N.N., Kataoka, Y., Murley, J.S., Weichselbaum, R.R., Grdina, D.J. Int. J. Radiat. Oncol. Biol. Phys. (2004)
- WR-1065, the active form of amifostine, protects HL-60 cells but not peripheral blood mononuclear cells from radiation and etoposide-induced apoptosis. Hatoum, G.F., Nevaldine, B., Bhavsar, T., Phung, Q., Hahn, P.J. Int. J. Radiat. Oncol. Biol. Phys. (2004)
- Differential radioprotection of cultured human diploid fibroblasts and fibrosarcoma cells by WR1065. Zhang, X., Lai, P.P., Taylor, Y.C. Int. J. Radiat. Oncol. Biol. Phys. (1992)
- Prostaglandins protect against murine hair injury produced by ionizing radiation or doxorubicin. Malkinson, F.D., Geng, L., Hanson, W.R. J. Invest. Dermatol. (1993)
- Protection from cellular oxidative injury and calcium intrusion by N-(2-mercaptoethyl)-1,3-propanediamine, WR 1065. Polla, B.S., Donati, Y., Kondo, M., Tochon-Danguy, H.J., Bonjour, J.P. Biochem. Pharmacol. (1990)
- The effect of 2-[(aminopropyl)amino] ethanethiol on fission-neutron-induced DNA damage and repair. Grdina, D.J., Sigdestad, C.P., Dale, P.J., Perrin, J.M. Br. J. Cancer (1989)
- Degradation of 2-(3-aminopropylamino)-ethanethiol (WR-1065) by Cu-dependent amine oxidases and influence on glutathione status of Chinese hamster ovary cells. Meier, T., Issels, R.D. Biochem. Pharmacol. (1995)
- Protective effects of 2-[(aminopropyl)amino] ethanethiol against bleomycin and nitrogen mustard-induced mutagenicity in V79 cells. Nagy, B., Grdina, D.J. Int. J. Radiat. Oncol. Biol. Phys. (1986)
- Delayed radioprotection by NFkappaB-mediated induction of Sod2 (MnSOD) in SA-NH tumor cells after exposure to clinically used thiol-containing drugs. Murley, J.S., Kataoka, Y., Cao, D., Li, J.J., Oberley, L.W., Grdina, D.J. Radiat. Res. (2004)
- Manganese Superoxide Dismutase (SOD2)-Mediated Delayed Radioprotection Induced by the Free Thiol Form of Amifostine and Tumor Necrosis Factor alpha. Murley, J.S., Kataoka, Y., Baker, K.L., Diamond, A.M., Morgan, W.F., Grdina, D.J. Radiat. Res. (2007)
- Effect of amifostine on the cytotoxicity of daunorubicin and daunoxome in tumor and normal cells. Angela, M., Raffaella, S., Anna, C., Mario, T., Elisabetta, C., Domenico, R., Renato, F., Daniela, D. Cancer Chemother. Pharmacol. (2006)
- Binding of the aminothiol WR-1065 to transcription factors influences cellular response to anticancer drugs. Shen, H., Chen, Z.J., Zilfou, J.T., Hopper, E., Murphy, M., Tew, K.D. J. Pharmacol. Exp. Ther. (2001)
- Lens epithelial cell protection by aminothiol WR-1065 and anetholedithiolethione from ionizing radiation. Belkacémi, Y., Rat, P., Piel, G., Christen, M.O., Touboul, E., Warnet, J.M. Int. J. Cancer (2001)
- HPLC assay for 2-(3-aminopropylamino)ethanethiol (WR-1065) in plasma. McGovern, E.P., Swynnerton, N.F., Steele, P.D., Mangold, D.J. Int. J. Radiat. Oncol. Biol. Phys. (1984)