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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function.

Lymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes. Mice deficient in IRF4 showed normal distribution of B and T lymphocyes at 4 to 5 weeks of age but developed progressive generalized lymphadenopathy. IRF4-deficient mice exhibited a profound reduction in serum immunoglobulin concentrations and did not mount detectable antibody responses. T lymphocyte function was also impaired in vivo; these mice could not generate cytotoxic or antitumor responses. Thus, IRF4 is essential for the function and homeostasis of both mature B and mature T lymphocytes.[1]

References

  1. Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Mittrücker, H.W., Matsuyama, T., Grossman, A., Kündig, T.M., Potter, J., Shahinian, A., Wakeham, A., Patterson, B., Ohashi, P.S., Mak, T.W. Science (1997) [Pubmed]
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