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Gene Review

Irf4  -  interferon regulatory factor 4

Mus musculus

Synonyms: AI385587, IRF-4, Interferon regulatory factor 4, LSIRF, Lymphocyte-specific interferon regulatory factor, ...
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Disease relevance of Irf4


High impact information on Irf4


Biological context of Irf4


Anatomical context of Irf4


Associations of Irf4 with chemical compounds

  • On the basis of the hydroxyl radical footprints in the ternary PU.1/IRF4/lambdaB complex, a model for the interactions between the two proteins and the lambdaB site was developed [12].

Physical interactions of Irf4

  • Crystal structure of PU.1/IRF-4/DNA ternary complex [13].
  • DNA microarray analyses enabled us to identify two genes inhibited by v-Abl that encode the Igk 3' enhancer-binding transcription factors Spi-B and IRF-4 [14].

Regulatory relationships of Irf4


Other interactions of Irf4

  • We report here the structure of the ternary complex formed with the DNA binding domains of PU.1 and IRF-4 on a composite DNA element [13].
  • These data indicate the critical role of NF kappa B and Irf4 in the regulation of IgE CSR through actions downstream of CpG signaling [11].
  • In vitro, activation of IRF4(-/-) CD4(+) Th cells led to greatly increased apoptosis compared with wild-type cells [2].
  • Nine IRFs have been described and they are expressed in a variety of cells, except for ICSBP and LSIRF/Pip, which are thought to be expressed exclusively in immune cells [16].
  • Plasma cell differentiation required IRF4 as well as the transcriptional repressor Blimp-1, which both acted 'upstream' of the transcription factor XBP-1 [10].

Analytical, diagnostic and therapeutic context of Irf4


  1. Negative regulation of Toll-like-receptor signaling by IRF-4. Negishi, H., Ohba, Y., Yanai, H., Takaoka, A., Honma, K., Yui, K., Matsuyama, T., Taniguchi, T., Honda, K. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Enhanced TCR-induced apoptosis in interferon regulatory factor 4-deficient CD4(+) Th cells. Lohoff, M., Mittrücker, H.W., Brüstle, A., Sommer, F., Casper, B., Huber, M., Ferrick, D.A., Duncan, G.S., Mak, T.W. J. Exp. Med. (2004) [Pubmed]
  3. Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4. Lohoff, M., Mittrücker, H.W., Prechtl, S., Bischof, S., Sommer, F., Kock, S., Ferrick, D.A., Duncan, G.S., Gessner, A., Mak, T.W. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  4. Expression of interferon regulatory factor 4 in chronic myeloid leukemia: correlation with response to interferon alfa therapy. Schmidt, M., Hochhaus, A., König-Merediz, S.A., Brendel, C., Proba, J., Hoppe, G.J., Wittig, B., Ehninger, G., Hehlmann, R., Neubauer, A. J. Clin. Oncol. (2000) [Pubmed]
  5. The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Brüstle, A., Heink, S., Huber, M., Rosenplänter, C., Stadelmann, C., Yu, P., Arpaia, E., Mak, T.W., Kamradt, T., Lohoff, M. Nat. Immunol. (2007) [Pubmed]
  6. Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Mittrücker, H.W., Matsuyama, T., Grossman, A., Kündig, T.M., Potter, J., Shahinian, A., Wakeham, A., Patterson, B., Ohashi, P.S., Mak, T.W. Science (1997) [Pubmed]
  7. Rel induces interferon regulatory factor 4 (IRF-4) expression in lymphocytes: modulation of interferon-regulated gene expression by rel/nuclear factor kappaB. Grumont, R.J., Gerondakis, S. J. Exp. Med. (2000) [Pubmed]
  8. Interferon regulatory factor 4 negatively regulates the production of proinflammatory cytokines by macrophages in response to LPS. Honma, K., Udono, H., Kohno, T., Yamamoto, K., Ogawa, A., Takemori, T., Kumatori, A., Suzuki, S., Matsuyama, T., Yui, K. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  9. Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE). Matsuyama, T., Grossman, A., Mittrücker, H.W., Siderovski, D.P., Kiefer, F., Kawakami, T., Richardson, C.D., Taniguchi, T., Yoshinaga, S.K., Mak, T.W. Nucleic Acids Res. (1995) [Pubmed]
  10. Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Klein, U., Casola, S., Cattoretti, G., Shen, Q., Lia, M., Mo, T., Ludwig, T., Rajewsky, K., Dalla-Favera, R. Nat. Immunol. (2006) [Pubmed]
  11. CpG inhibits IgE class switch recombination through suppression of NF kappa B activity, but not through Id2 or Bcl6. Kusunoki, T., Sugai, M., Gonda, H., Nambu, Y., Nagata-Nakajima, N., Katakai, T., Kusunoki, M., Sakamoto, A., Tokuhisa, T., Nakahata, T., Yokota, Y., Shimizu, A. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  12. Quantitative hydroxyl radical footprinting reveals cooperative interactions between DNA-binding subdomains of PU.1 and IRF4. Gross, P., Yee, A.A., Arrowsmith, C.H., Macgregor, R.B. Biochemistry (1998) [Pubmed]
  13. Crystal structure of PU.1/IRF-4/DNA ternary complex. Escalante, C.R., Brass, A.L., Pongubala, J.M., Shatova, E., Shen, L., Singh, H., Aggarwal, A.K. Mol. Cell (2002) [Pubmed]
  14. A small molecule Abl kinase inhibitor induces differentiation of Abelson virus-transformed pre-B cell lines. Muljo, S.A., Schlissel, M.S. Nat. Immunol. (2003) [Pubmed]
  15. Active inhibition of plasma cell development in resting B cells by microphthalmia-associated transcription factor. Lin, L., Gerth, A.J., Peng, S.L. J. Exp. Med. (2004) [Pubmed]
  16. Interferon regulatory transcription factors are constitutively expressed and spatially regulated in the mouse lens. Li, W., Nagineni, C.N., Efiok, B., Chepelinsky, A.B., Egwuagu, C.E. Dev. Biol. (1999) [Pubmed]
  17. Crystallization and characterization of PU.1/IRF-4/DNA ternary complex. Escalante, C.R., Shen, L., Escalante, M.C., Brass, A.L., Edwards, T.A., Singh, H., Aggarwal, A.K. J. Struct. Biol. (2002) [Pubmed]
  18. Development of Th1 and not Th2 immune responses in mice lacking IFN-regulatory factor-4. Tominaga, N., Ohkusu-Tsukada, K., Udono, H., Abe, R., Matsuyama, T., Yui, K. Int. Immunol. (2003) [Pubmed]
  19. IFN Regulatory Factor 4 and 8 Promote Ig Light Chain {kappa} Locus Activation in Pre-B Cell Development. Ma, S., Turetsky, A., Trinh, L., Lu, R. J. Immunol. (2006) [Pubmed]
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