Gene Review:
Irf4 - interferon regulatory factor 4
Mus musculus
Synonyms:
AI385587, IRF-4, Interferon regulatory factor 4, LSIRF, Lymphocyte-specific interferon regulatory factor, ...
- Negative regulation of Toll-like-receptor signaling by IRF-4. Negishi, H., Ohba, Y., Yanai, H., Takaoka, A., Honma, K., Yui, K., Matsuyama, T., Taniguchi, T., Honda, K. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Enhanced TCR-induced apoptosis in interferon regulatory factor 4-deficient CD4(+) Th cells. Lohoff, M., Mittrücker, H.W., Brüstle, A., Sommer, F., Casper, B., Huber, M., Ferrick, D.A., Duncan, G.S., Mak, T.W. J. Exp. Med. (2004)
- Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4. Lohoff, M., Mittrücker, H.W., Prechtl, S., Bischof, S., Sommer, F., Kock, S., Ferrick, D.A., Duncan, G.S., Gessner, A., Mak, T.W. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Expression of interferon regulatory factor 4 in chronic myeloid leukemia: correlation with response to interferon alfa therapy. Schmidt, M., Hochhaus, A., König-Merediz, S.A., Brendel, C., Proba, J., Hoppe, G.J., Wittig, B., Ehninger, G., Hehlmann, R., Neubauer, A. J. Clin. Oncol. (2000)
- The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Brüstle, A., Heink, S., Huber, M., Rosenplänter, C., Stadelmann, C., Yu, P., Arpaia, E., Mak, T.W., Kamradt, T., Lohoff, M. Nat. Immunol. (2007)
- Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Mittrücker, H.W., Matsuyama, T., Grossman, A., Kündig, T.M., Potter, J., Shahinian, A., Wakeham, A., Patterson, B., Ohashi, P.S., Mak, T.W. Science (1997)
- Rel induces interferon regulatory factor 4 (IRF-4) expression in lymphocytes: modulation of interferon-regulated gene expression by rel/nuclear factor kappaB. Grumont, R.J., Gerondakis, S. J. Exp. Med. (2000)
- Interferon regulatory factor 4 negatively regulates the production of proinflammatory cytokines by macrophages in response to LPS. Honma, K., Udono, H., Kohno, T., Yamamoto, K., Ogawa, A., Takemori, T., Kumatori, A., Suzuki, S., Matsuyama, T., Yui, K. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE). Matsuyama, T., Grossman, A., Mittrücker, H.W., Siderovski, D.P., Kiefer, F., Kawakami, T., Richardson, C.D., Taniguchi, T., Yoshinaga, S.K., Mak, T.W. Nucleic Acids Res. (1995)
- Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Klein, U., Casola, S., Cattoretti, G., Shen, Q., Lia, M., Mo, T., Ludwig, T., Rajewsky, K., Dalla-Favera, R. Nat. Immunol. (2006)
- CpG inhibits IgE class switch recombination through suppression of NF kappa B activity, but not through Id2 or Bcl6. Kusunoki, T., Sugai, M., Gonda, H., Nambu, Y., Nagata-Nakajima, N., Katakai, T., Kusunoki, M., Sakamoto, A., Tokuhisa, T., Nakahata, T., Yokota, Y., Shimizu, A. Biochem. Biophys. Res. Commun. (2005)
- Quantitative hydroxyl radical footprinting reveals cooperative interactions between DNA-binding subdomains of PU.1 and IRF4. Gross, P., Yee, A.A., Arrowsmith, C.H., Macgregor, R.B. Biochemistry (1998)
- Crystal structure of PU.1/IRF-4/DNA ternary complex. Escalante, C.R., Brass, A.L., Pongubala, J.M., Shatova, E., Shen, L., Singh, H., Aggarwal, A.K. Mol. Cell (2002)
- A small molecule Abl kinase inhibitor induces differentiation of Abelson virus-transformed pre-B cell lines. Muljo, S.A., Schlissel, M.S. Nat. Immunol. (2003)
- Active inhibition of plasma cell development in resting B cells by microphthalmia-associated transcription factor. Lin, L., Gerth, A.J., Peng, S.L. J. Exp. Med. (2004)
- Interferon regulatory transcription factors are constitutively expressed and spatially regulated in the mouse lens. Li, W., Nagineni, C.N., Efiok, B., Chepelinsky, A.B., Egwuagu, C.E. Dev. Biol. (1999)
- Crystallization and characterization of PU.1/IRF-4/DNA ternary complex. Escalante, C.R., Shen, L., Escalante, M.C., Brass, A.L., Edwards, T.A., Singh, H., Aggarwal, A.K. J. Struct. Biol. (2002)
- Development of Th1 and not Th2 immune responses in mice lacking IFN-regulatory factor-4. Tominaga, N., Ohkusu-Tsukada, K., Udono, H., Abe, R., Matsuyama, T., Yui, K. Int. Immunol. (2003)
- IFN Regulatory Factor 4 and 8 Promote Ig Light Chain {kappa} Locus Activation in Pre-B Cell Development. Ma, S., Turetsky, A., Trinh, L., Lu, R. J. Immunol. (2006)