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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The topoisomerase I gene from Candida albicans.

We report here the cloning of the Candida albicans genomic topoisomerase I gene (TOP1) by use of PCR and subsequent hybridization. The predicted protein sequence shared 58.8% identity with the Saccharomyces cerevisiae topoisomerase I and 30-50% identity with other eukaryotic topoisomerase I proteins. A conditional gene disruption strain (CWJ477) was constructed so that one copy of TOP1 was deleted and the other copy of TOP1 was placed under a regulatable promoter. Under repressed conditions, cells grew slowly and cell morphology was abnormal. The virulence of CWJ477 was markedly reduced in a mouse model system, and that of the single gene knockout-strain was slightly attenuated, indicating that TOP1 might play a role in the infection of C. albicans in mice in a dose-dependent manner. Despite the reduced virulence of both the single and double knockout strains, viable cells of the pathogen were recovered from the kidneys as late as 22 d post-infection.[1]


  1. The topoisomerase I gene from Candida albicans. Jiang, W., Gerhold, D., Kmiec, E.B., Hauser, M., Becker, J.M., Koltin, Y. Microbiology (Reading, Engl.) (1997) [Pubmed]
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