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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells.

Clinical deterioration in human immunodeficiency virus type 1 (HIV-1) infection is associated with increased levels of viral replication and burden in the peripheral blood and lymphoid organs. T cell activation and ensuing cellular gene activation can be critical for HIV-1 replication. The hypothesis that the nuclear factor of activated T cells (NF-AT) may influence HIV-1 replication is therefore compelling given the tight correlation of HIV-1 transcriptional induction to T cell activation. We report that certain NF-AT(Rel) family members productively bind the kappaB regulatory elements, synergize with NF-kappaB and Tat in transcriptional activation of HIV-1, and enhance HIV-1 replication in T cells. These results link regulatory factors critical to T cell commitment directly to HIV-1 replication.[1]

References

  1. The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells. Kinoshita, S., Su, L., Amano, M., Timmerman, L.A., Kaneshima, H., Nolan, G.P. Immunity (1997) [Pubmed]
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