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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Role of Drosophila alpha-adaptin in presynaptic vesicle recycling.

Rapid flow of information in the nervous system involves presynaptic vesicle recycling by clathrin-mediated endocytosis, an event triggered by the alpha-adaptin-containing AP2 complex. We identified a Drosophila alpha-adaptin expressed in the garland cells, imaginal discs, and the CNS. Here we show its role in presynaptic vesicle recycling. In presynaptic terminals, alpha-adaptin defines a network-like membrane structure to which the GTPase dynamin is recruited. alpha-adaptin is necessary for the formation of clathrin-coated pits and participates in the dynamin-dependent release of coated vesicles from the membrane surface. Our results suggest an alpha-adaptin-dependent control of the vesicle cycle that maintains the balance between the amount of vesicle- and surface-associated membranes.[1]


  1. Role of Drosophila alpha-adaptin in presynaptic vesicle recycling. González-Gaitán, M., Jäckle, H. Cell (1997) [Pubmed]
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