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MeSH Review

Coated Vesicles

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Disease relevance of Coated Vesicles


Psychiatry related information on Coated Vesicles


High impact information on Coated Vesicles

  • When this coating is exaggerated by GTP gamma S, the periphery of all cisternae is partitioned into coated vesicles that remain attached at their sites of formation [4].
  • Annexin VI appears to be not only an active component in the detachment of coated pits from the membrane but also a site for regulating the formation of coated vesicles [5].
  • Our results show that LCa is more important for interactions with hsc70 than is LCb and suggest a model in which the LCa conformation regulates coated vesicle uncoating [6].
  • We used a cholinesterase-mediated density shift protocol to investigate the movement of internalized transferrin (Tf) through endo- and exocytic coated vesicles (CVs) in the perfused rat liver [7].
  • The two coated vesicle classes have very similar polypeptide compositions but differ significantly in the ratio of cholesterol to phospholipid [8].

Chemical compound and disease context of Coated Vesicles

  • Metabotropic glutamate receptor analogues inhibit p[NH]ppG-stimulated phospholipase C activity in bovine brain coated vesicles: involvement of a pertussis toxin-sensitive G-protein [1].
  • Preincubation of coated vesicles with pertussis toxin blocked the poorly-hydrolyzable GTP-analogs' inhibitory effects on phospholipase C. These data indicate that guanine nucleotides exert a dual regulatory control of phospholipase C in coated vesicles and that the inhibitory pathway is mediated by a pertussis toxin-sensitive G-protein [9].

Biological context of Coated Vesicles


Anatomical context of Coated Vesicles


Associations of Coated Vesicles with chemical compounds

  • Coated vesicles isolated from rat liver perfused with diisopropylfluorophosphate (DFP) to inactivate endogenous cholinesterase contained newly synthesized secretory cholinesterase after a 30 min recovery [8].
  • In contrast, apical membrane endocytic pits and coated vesicles in M cells failed to show filipin-induced membrane lesions [20].
  • The addition of Triton X-100 to coated vesicles or to stripped vesicles from which 90% of the clathrin had been removed resulted in the release of four distinct polypeptides of approximate Mr 38,000, 29,000, 24,000 and 10,000 [21].
  • However, coated vesicles treated with the detergent octyl glucoside exhibit a substantial specific 125I-insulin binding capacity [22].
  • Tannic acid staining reveals that the coats of coated vesicles, pits, and plaques have a 12-nm layer of amorphous material between the membrane and the clathrin basketwork [23].

Gene context of Coated Vesicles


Analytical, diagnostic and therapeutic context of Coated Vesicles


  1. Metabotropic glutamate receptor analogues inhibit p[NH]ppG-stimulated phospholipase C activity in bovine brain coated vesicles: involvement of a pertussis toxin-sensitive G-protein. Martín, M., Sanz, J.M., Ros, M., Cubero, A. Biochem. J. (1995) [Pubmed]
  2. Lysosome-associated membrane protein-1 (LAMP-1) is the melanocyte vesicular membrane glycoprotein band II. Zhou, B.K., Boissy, R.E., Pifko-Hirst, S., Moran, D.J., Orlow, S.J. J. Invest. Dermatol. (1993) [Pubmed]
  3. Alzheimer's disease: coated vesicles, coated pits and the amyloid-related cell. Roher, A., Gray, E.G., Paula-Barbosa, M. Proc. R. Soc. Lond., B, Biol. Sci. (1988) [Pubmed]
  4. Golgi membrane dynamics imaged by freeze-etch electron microscopy: views of different membrane coatings involved in tubulation versus vesiculation. Weidman, P., Roth, R., Heuser, J. Cell (1993) [Pubmed]
  5. Annexin VI is required for budding of clathrin-coated pits. Lin, H.C., Südhof, T.C., Anderson, R.G. Cell (1992) [Pubmed]
  6. Uncoating protein (hsc70) binds a conformationally labile domain of clathrin light chain LCa to stimulate ATP hydrolysis. DeLuca-Flaherty, C., McKay, D.B., Parham, P., Hill, B.L. Cell (1990) [Pubmed]
  7. A trans Golgi-derived exocytic coated vesicle can contain both newly synthesized cholinesterase and internalized transferrin. Fishman, J.B., Fine, R.E. Cell (1987) [Pubmed]
  8. Separation of endocytic from exocytic coated vesicles using a novel cholinesterase mediated density shift technique. Helmy, S., Porter-Jordan, K., Dawidowicz, E.A., Pilch, P., Schwartz, A.L., Fine, R.E. Cell (1986) [Pubmed]
  9. Presence of phospholipase C in coated vesicles from bovine brain. Dual regulatory effects of GTP-analogs. Martin, M., Ros, M., González-Calero, G., Cubero, A. FEBS Lett. (1991) [Pubmed]
  10. The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking. Gaidarov, I., Smith, M.E., Domin, J., Keen, J.H. Mol. Cell (2001) [Pubmed]
  11. Role of coated vesicles, microfilaments, and calmodulin in receptor-mediated endocytosis by cultured B lymphoblastoid cells. Salisbury, J.L., Condeelis, J.S., Satir, P. J. Cell Biol. (1980) [Pubmed]
  12. Membrane activity and topography of F-Met-Leu-Phe-Treated polymorphonuclear leukocytes. Acute and sustained responses to chemotactic peptide. Davis, B.H., Walter, R.J., Pearson, C.B., Becker, E.L., Oliver, J.M. Am. J. Pathol. (1982) [Pubmed]
  13. HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes. Janvier, K., Craig, H., Hitchin, D., Madrid, R., Sol-Foulon, N., Renault, L., Cherfils, J., Cassel, D., Benichou, S., Guatelli, J. J. Biol. Chem. (2003) [Pubmed]
  14. Rabphilin-3A: a multifunctional regulator of synaptic vesicle traffic. Burns, M.E., Sasaki, T., Takai, Y., Augustine, G.J. J. Gen. Physiol. (1998) [Pubmed]
  15. Differential postendocytotic compartmentation in Xenopus oocytes is mediated by a specifically bound ligand. Opresko, L., Wiley, H.S., Wallace, R.A. Cell (1980) [Pubmed]
  16. LDL receptors in coated vesicles isolated from bovine adrenal cortex: binding sites unmasked by detergent treatment. Mello, R.J., Brown, M.S., Goldstein, J.L., Anderson, R.G. Cell (1980) [Pubmed]
  17. The role of clathrin, adaptors and dynamin in endocytosis. Robinson, M.S. Curr. Opin. Cell Biol. (1994) [Pubmed]
  18. Ras-related proteins. Hall, A. Curr. Opin. Cell Biol. (1993) [Pubmed]
  19. The lectin ERGIC-53 is a cargo transport receptor for glycoproteins. Appenzeller, C., Andersson, H., Kappeler, F., Hauri, H.P. Nat. Cell Biol. (1999) [Pubmed]
  20. Structural features of and cholesterol distribution in M-cell membranes in guinea pig, rat, and mouse Peyer's patches. Madara, J.L., Bye, W.A., Trier, J.S. Gastroenterology (1984) [Pubmed]
  21. Solubilization of proteins from bovine brain coated vesicles by protein perturbants and Triton X-100. Wiedenmann, B., Lawley, K., Grund, C., Branton, D. J. Cell Biol. (1985) [Pubmed]
  22. Coated vesicles participate in the receptor-mediated endocytosis of insulin. Pilch, P.F., Shia, M.A., Benson, R.J., Fine, R.E. J. Cell Biol. (1983) [Pubmed]
  23. Improved preservation and staining of HeLa cell actin filaments, clathrin-coated membranes, and other cytoplasmic structures by tannic acid-glutaraldehyde-saponin fixation. Maupin, P., Pollard, T.D. J. Cell Biol. (1983) [Pubmed]
  24. The role of dynamin and its binding partners in coated pit invagination and scission. Hill, E., van Der Kaay, J., Downes, C.P., Smythe, E. J. Cell Biol. (2001) [Pubmed]
  25. Female sterile (1) yolkless: a recessive female sterile mutation in Drosophila melanogaster with depressed numbers of coated pits and coated vesicles within the developing oocytes. DiMario, P.J., Mahowald, A.P. J. Cell Biol. (1987) [Pubmed]
  26. Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4. Signoret, N., Oldridge, J., Pelchen-Matthews, A., Klasse, P.J., Tran, T., Brass, L.F., Rosenkilde, M.M., Schwartz, T.W., Holmes, W., Dallas, W., Luther, M.A., Wells, T.N., Hoxie, J.A., Marsh, M. J. Cell Biol. (1997) [Pubmed]
  27. GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex. Dell'Angelica, E.C., Puertollano, R., Mullins, C., Aguilar, R.C., Vargas, J.D., Hartnell, L.M., Bonifacino, J.S. J. Cell Biol. (2000) [Pubmed]
  28. BIG2, a guanine nucleotide exchange factor for ADP-ribosylation factors: its localization to recycling endosomes and implication in the endosome integrity. Shin, H.W., Morinaga, N., Noda, M., Nakayama, K. Mol. Biol. Cell (2004) [Pubmed]
  29. Detection of membrane cholesterol by filipin in isolated rat liver coated vesicles is dependent upon removal of the clathrin coat. Steer, C.J., Bisher, M., Blumenthal, R., Steven, A.C. J. Cell Biol. (1984) [Pubmed]
  30. Purification and properties of 100-kd proteins from coated vesicles and their reconstitution with clathrin. Pearse, B.M., Robinson, M.S. EMBO J. (1984) [Pubmed]
  31. Transmembrane orientation of the mannose 6-phosphate receptor in isolated clathrin-coated vesicles. Sahagian, G.G., Steer, C.J. J. Biol. Chem. (1985) [Pubmed]
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