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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Evidence for local production of acute phase response apolipoprotein serum amyloid A in Alzheimer's disease brain.

Acute phase serum amyloid A (A-apoSAA), but not constitutive apoSAA (C-apoSAA), was identified by Western blotting experiments in brain protein extracts from eight of nine patients with Alzheimer's disease (AD), one with a brain tumor and one with multiple sclerosis. A-apoSAA was not detected in six subjects with Pick's or Lewy Body disease or three other non-AD brain specimens. Apolipoprotein A-I and albumin were not found in any of the brain protein extracts. A-apoSAA mRNA was detected in AD brain by reverse transcription-polymerase chain reaction (RT-PCR). These data suggest that apoSAA is locally produced in AD brain and that investigation of the neuroinflammatory effects of this injury specific apolipoprotein is warranted.[1]

References

  1. Evidence for local production of acute phase response apolipoprotein serum amyloid A in Alzheimer's disease brain. Liang, J.S., Sloane, J.A., Wells, J.M., Abraham, C.R., Fine, R.E., Sipe, J.D. Neurosci. Lett. (1997) [Pubmed]
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