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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.

A C. elegans neurosecretory signaling system regulates whether animals enter the reproductive life cycle or arrest development at the long-lived dauer diapause stage. daf-2, a key gene in the genetic pathway that mediates this endocrine signaling, encodes an insulin receptor family member. Decreases in DAF-2 signaling induce metabolic and developmental changes, as in mammalian metabolic control by the insulin receptor. Decreased DAF-2 signaling also causes an increase in life-span. Life-span regulation by insulin-like metabolic control is analogous to mammalian longevity enhancement induced by caloric restriction, suggesting a general link between metabolism, diapause, and longevity.[1]

References

  1. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Kimura, K.D., Tissenbaum, H.A., Liu, Y., Ruvkun, G. Science (1997) [Pubmed]
 
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