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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Orthovanadate induces cell death in rat dentate gyrus primary culture.

The aim of this study was to define the effects of a potent inhibitor of tyrosine phosphatases, sodium orthovanadate (0.1-100 microM for up to 48 h), on dentate gyrus cells (DGC) in culture. Treatment with 100 microM orthovanadate evoked a delayed form of cell death. To examine the possible involvement of apoptosis in orthovanadate-induced cell death, biochemical and morphological alterations were compared with those of necrotic death induced by sodium azide. Phase-contrast microscopy and nuclear condensation analysis showed that orthovanadate and azide each evoked cell death by distinct pathways. TUNEL assay was positive in both cases. Application of a protein synthesis inhibitor, cycloheximide, did not prevent cytotoxicity caused by either orthovanadate or azide and potentiated the effects of vanadate. We conclude that orthovanadate-induced death of DGC bears features of apoptosis.[1]


  1. Orthovanadate induces cell death in rat dentate gyrus primary culture. Figiel, I., Kaczmarek, L. Neuroreport (1997) [Pubmed]
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