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Chemical Compound Review

CHEBI:46442     trioxido-oxo-vanadium

Synonyms: CHEBI:745803, AC1L1VPA, VO4(3+), trioxido(oxo)vanadium, Vanadium (V) tetraoxide
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Disease relevance of Vanadate

  • The antiproliferative effect, like S1P-mediated ERK1/2 inhibition, was orthovanadate-sensitive and pertussis toxin-insensitive [1].
  • To investigate this question, we have used a baculovirus dual expression vector encoding both halves of MRP1 to reconstitute an active transporter and have compared the ability of each NBD to be photoaffinity-labeled with 8-azido-[(32)P]ATP and to trap 8-azido-[(32)P]ADP in the presence of orthovanadate [2].
  • Whereas parenterally administered orthovanadate or vanadyl sulfate did not induce hypoglycemia before inducing acute mortality, pV compounds effected hypoglycemia at doses much lower than those inducing acute mortality [3].
  • The bacterial-expressed hPTP sigma exhibits PTPase activity that was inhibited by orthovanadate (IC50 = 0.02 microM) and by two bisphosphonates used for the treatment of bone diseases, alendronate (ALN) (IC50 = 0.5 microM) and etidronate (IC50 = 0.2 microM) [4].
  • The orthovanadate injection administered before ischemia inhibited its binding activity [5].

High impact information on Vanadate


Chemical compound and disease context of Vanadate


Biological context of Vanadate


Anatomical context of Vanadate


Associations of Vanadate with other chemical compounds


Gene context of Vanadate

  • Mitogen-activated protein kinase (MAPK) was poorly activated by orthovanadate, and inhibition of MAPK with PD98059 blocked proliferation without inducing apoptosis [15].
  • Thus, orthovanadate likely acts to greatly increase JAK/STAT and PI-3 kinase basal activity in untreated cells by blocking tyrosine protein phosphatase activity [15].
  • Upon activation of signaling by IL-6 or orthovanadate the respective Tyr-phosphorylated STAT species were now also observed in the membrane raft fraction but in a form deficient in DNA binding [25].
  • Photoaffinity labeling of W590S with 8-azido-[alpha-(32)P]ATP was stimulated by adding ortho-vanadate in the presence of Mn(2+) as much as in the presence of wild-type ABCA1 [26].
  • Pretreatment of CCR5 L1.2 transfectants or T-cells with the phosphatase inhibitor orthovanadate markedly abolished MIP1beta-induced chemotaxis [27].

Analytical, diagnostic and therapeutic context of Vanadate


  1. Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors. Malek, R.L., Toman, R.E., Edsall, L.C., Wong, S., Chiu, J., Letterle, C.A., Van Brocklyn, J.R., Milstien, S., Spiegel, S., Lee, N.H. J. Biol. Chem. (2001) [Pubmed]
  2. Comparison of the functional characteristics of the nucleotide binding domains of multidrug resistance protein 1. Gao, M., Cui, H.R., Loe, D.W., Grant, C.E., Almquist, K.C., Cole, S.P., Deeley, R.G. J. Biol. Chem. (2000) [Pubmed]
  3. Hypoglycemic effects of peroxovanadium compounds in Sprague-Dawley and diabetic BB rats. Yale, J.F., Lachance, D., Bevan, A.P., Vigeant, C., Shaver, A., Posner, B.I. Diabetes (1995) [Pubmed]
  4. Human protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonates. Endo, N., Rutledge, S.J., Opas, E.E., Vogel, R., Rodan, G.A., Schmidt, A. J. Bone Miner. Res. (1996) [Pubmed]
  5. Decreased akt activity is associated with activation of forkhead transcription factor after transient forebrain ischemia in gerbil hippocampus. Kawano, T., Morioka, M., Yano, S., Hamada, J., Ushio, Y., Miyamoto, E., Fukunaga, K. J. Cereb. Blood Flow Metab. (2002) [Pubmed]
  6. Effects of ATP and vanadate on calcium efflux from barnacle muscle fibres. Nelson, M.T., Blaustein, M.P. Nature (1981) [Pubmed]
  7. Vanadate inhibits uncoupled Ca efflux but not Na--Ca exchange in squid axons. DiPolo, R., Rojas, H.R., Beaugé, L. Nature (1979) [Pubmed]
  8. Leukocyte common antigen (CD45) is required for immunoglobulin E-mediated degranulation of mast cells. Berger, S.A., Mak, T.W., Paige, C.J. J. Exp. Med. (1994) [Pubmed]
  9. NGF and other growth factors induce an association between ERK1 and the NGF receptor, gp140prototrk. Loeb, D.M., Tsao, H., Cobb, M.H., Greene, L.A. Neuron (1992) [Pubmed]
  10. Effect of nerve growth factor and fibroblast growth factor on PC12 cells: inhibition by orthovanadate. Wu, Y.Y., Bradshaw, R.A. J. Cell Biol. (1993) [Pubmed]
  11. G protein coupled receptor signaled apoptosis is associated with activation of a cation insensitive acidic endonuclease and intracellular acidification. Sharma, K., Srikant, C.B. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  12. Isoniazid accumulation in Mycobacterium smegmatis is modulated by proton motive force-driven and ATP-dependent extrusion systems. Choudhuri, B.S., Sen, S., Chakrabarti, P. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  13. Reconstitution of the lysosomal proton pump. D'Souza, M.P., Ambudkar, S.V., August, J.T., Maloney, P.C. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  14. Vanadate-resistant yeast mutants are defective in protein glycosylation. Ballou, L., Hitzeman, R.A., Lewis, M.S., Ballou, C.E. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  15. Phosphatase inhibition promotes antiapoptotic but not proliferative signaling pathways in erythropoietin-dependent HCD57 cells. Lawson, A.E., Bao, H., Wickrema, A., Jacobs-Helber, S.M., Sawyer, S.T. Blood (2000) [Pubmed]
  16. Proteome analysis of nuclear matrix proteins during apoptotic chromatin condensation. Gerner, C., Gotzmann, J., Fröhwein, U., Schamberger, C., Ellinger, A., Sauermann, G. Cell Death Differ. (2002) [Pubmed]
  17. Intramolecular cross-linking of domains at the active site links A1 and B subfragments of the Ca2+-ATPase of sarcoplasmic reticulum. Ross, D.C., McIntosh, D.B. J. Biol. Chem. (1987) [Pubmed]
  18. Reaction sequence and molecular mass of a Cl(-)-translocating P-type ATPase. Gerencser, G.A., Zelezna, B. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  19. Phosphatase inhibitors remove the run-down of gamma-aminobutyric acid type A receptors in the human epileptic brain. Palma, E., Ragozzino, D.A., Di Angelantonio, S., Spinelli, G., Trettel, F., Martinez-Torres, A., Torchia, G., Arcella, A., Di Gennaro, G., Quarato, P.P., Esposito, V., Cantore, G., Miledi, R., Eusebi, F. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  20. Identification and characterization of a mitogen-activated S6 kinase. Jenö, P., Ballou, L.M., Novak-Hofer, I., Thomas, G. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  21. Phosphatase-mediated enhancement of cardiac cAMP-activated Cl-conductance by a Cl- channel blocker, anthracene-9-carboxylate. Zhou, S.S., Takai, A., Tominaga, M., Okada, Y. Circ. Res. (1997) [Pubmed]
  22. Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human. Laporte, J., Blondeau, F., Buj-Bello, A., Tentler, D., Kretz, C., Dahl, N., Mandel, J.L. Hum. Mol. Genet. (1998) [Pubmed]
  23. Phosphatase inhibitors modulate the growth-regulatory effects of human tumor necrosis factor on tumor and normal cells. Totpal, K., Agarwal, S., Aggarwal, B.B. Cancer Res. (1992) [Pubmed]
  24. Efficient purification and reconstitution of P-glycoprotein for functional and structural studies. Dong, M., Penin, F., Baggetto, L.G. J. Biol. Chem. (1996) [Pubmed]
  25. Cytokine signaling: STATS in plasma membrane rafts. Sehgal, P.B., Guo, G.G., Shah, M., Kumar, V., Patel, K. J. Biol. Chem. (2002) [Pubmed]
  26. Effects of mutations of ABCA1 in the first extracellular domain on subcellular trafficking and ATP binding/hydrolysis. Tanaka, A.R., Abe-Dohmae, S., Ohnishi, T., Aoki, R., Morinaga, G., Okuhira, K., Ikeda, Y., Kano, F., Matsuo, M., Kioka, N., Amachi, T., Murata, M., Yokoyama, S., Ueda, K. J. Biol. Chem. (2003) [Pubmed]
  27. Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk. Ganju, R.K., Brubaker, S.A., Chernock, R.D., Avraham, S., Groopman, J.E. J. Biol. Chem. (2000) [Pubmed]
  28. Selective activation of the JNK/AP-1 pathway in Fas-mediated apoptosis of rheumatoid arthritis synoviocytes. Okamoto, K., Fujisawa, K., Hasunuma, T., Kobata, T., Sumida, T., Nishioka, K. Arthritis Rheum. (1997) [Pubmed]
  29. Neuroprotective effect of postischemic administration of sodium orthovanadate in rats with transient middle cerebral artery occlusion. Hasegawa, Y., Hamada, J., Morioka, M., Yano, S., Kawano, T., Kai, Y., Fukunaga, K., Ushio, Y. J. Cereb. Blood Flow Metab. (2003) [Pubmed]
  30. Neuroprotective effect of sodium orthovanadate on delayed neuronal death after transient forebrain ischemia in gerbil hippocampus. Kawano, T., Fukunaga, K., Takeuchi, Y., Morioka, M., Yano, S., Hamada, J., Ushio, Y., Miyamoto, E. J. Cereb. Blood Flow Metab. (2001) [Pubmed]
  31. Protein tyrosine phosphatase regulation of endothelial cell apoptosis and differentiation. Yang, C., Chang, J., Gorospe, M., Passaniti, A. Cell Growth Differ. (1996) [Pubmed]
  32. Orthovanadate induces cell death in rat dentate gyrus primary culture. Figiel, I., Kaczmarek, L. Neuroreport (1997) [Pubmed]
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