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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Proadrenomedullin N-terminal 20-peptide (PAMP) receptors and signal transduction in the rat adrenal gland.

Using ligand binding techniques we have demonstrated specific saturable binding of proadrenomedullin N-terminal 20-peptide (PAMP) in the rat adrenal zona glomerulosa. Hill plot analysis revealed two classes of receptor (Kd1 1.9nmol/l Bmax 53fmol/mg protein: Kd2 10nmol/l, Bmax 225fmol/mg). [125 I]-PAMP was displaced by adrenomedullin at one of these receptors. In the adrenal medulla [125 I]-PAMP bound to a single class of specific receptor (Kd 4.9 nmol/l: Bmax 556fmol/mg). PAMP caused an increase in cAMP generation by zona glomerulosa cells, but not inner zone/medulla cells. These data suggest that PAMP acts through a specific receptor to elevate cAMP levels in the rat adrenal.[1]

References

  1. Proadrenomedullin N-terminal 20-peptide (PAMP) receptors and signal transduction in the rat adrenal gland. Hinson, J.P., Hagi-Pavli, E., Thomson, L.M., Kapas, S. Life Sci. (1998) [Pubmed]
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