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Gene Review

Adm  -  adrenomedullin

Rattus norvegicus

Synonyms: ADM, Ap, H39316, RATAP
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Disease relevance of Adm


Psychiatry related information on Adm


High impact information on Adm

  • Thus, it suggests that PAMP and adrenomedullin, which are derived from the same gene, exhibit different hypotensive mechanisms: PAMP inhibits neural transmission at peripheral sympathetic nerve ending, although adrenomedullin directly dilates vascular smooth muscle, possibly through CGRP-like receptor [7].
  • Proadrenomedullin NH(2)-terminal 20 peptide, a new product of the adrenomedullin gene, inhibits norepinephrine overflow from nerve endings [7].
  • In contrast, vasoconstrictive response of mesenteric arteries to exogenous norepinephrine was significantly attenuated by 10 pmol/ml of adrenomedullin but not by the same dose of PAMP [7].
  • Calcitonin gene-related peptide (CGRP), a widespread neuropeptide with multiple actions, has substantial homology with amylin, a peptide implicated in insulin-resistant diabetes, and adrenomedullin, a recently discovered potent vasodilator [8].
  • Superfusion of atrial myocytes with ADM (1 nmol/L) in isolated left atrial preparations resulted in a marked prolongation of action potential duration between 10 and -50 mV transmembrane voltage, consistent with an increase in L-type Ca2+ channel current during the plateau [9].

Chemical compound and disease context of Adm


Biological context of Adm


Anatomical context of Adm


Associations of Adm with chemical compounds


Physical interactions of Adm


Regulatory relationships of Adm


Other interactions of Adm


Analytical, diagnostic and therapeutic context of Adm


  1. Response of adrenomedullin system to cytokine in cardiac fibroblasts-role of adrenomedullin as an antifibrotic factor. Nishikimi, T., Tadokoro, K., Akimoto, K., Mori, Y., Ishikawa, Y., Ishimura, K., Horio, T., Kangawa, K., Matsuoka, H. Cardiovasc. Res. (2005) [Pubmed]
  2. Relationship between contents of adrenomedullin and distributions of neutral endopeptidase in blood and tissues of rats in septic shock. Jiang, W., Jiang, H.F., Cai, D.Y., Pan, C.S., Qi, Y.F., Pang, Y.Z., Tang, C.S. Regul. Pept. (2004) [Pubmed]
  3. Changes of adrenomedullin and receptor activity modifying protein 2 (RAMP2) in myocardium and aorta in rats with isoproterenol-induced myocardial ischemia. Qi, Y.F., Shi, Y.R., Bu, D.F., Pang, Y.Z., Tang, C.S. Peptides (2003) [Pubmed]
  4. Increased gene expression of adrenomedullin and adrenomedullin-receptor complexes, receptor-activity modifying protein (RAMP)2 and calcitonin-receptor-like receptor (CRLR) in the hearts of rats with congestive heart failure. Totsune, K., Takahashi, K., Mackenzie, H.S., Murakami, O., Arihara, Z., Sone, M., Mouri, T., Brenner, B.M., Ito, S. Clin. Sci. (2000) [Pubmed]
  5. Differential expression of adrenomedullin and its receptors in newborn and adult rat thymus. Carraro, G., Albertin, G., Bova, S., Malendowicz, L.K., Belloni, A.S., Nussdorfer, G.G. Int. J. Mol. Med. (2002) [Pubmed]
  6. The novel vasoactive hormone, adrenomedullin, inhibits water drinking in the rat. Murphy, T.C., Samson, W.K. Endocrinology (1995) [Pubmed]
  7. Proadrenomedullin NH(2)-terminal 20 peptide, a new product of the adrenomedullin gene, inhibits norepinephrine overflow from nerve endings. Shimosawa, T., Ito, Y., Ando, K., Kitamura, K., Kangawa, K., Fujita, T. J. Clin. Invest. (1995) [Pubmed]
  8. Pharmacology of receptors for calcitonin gene-related peptide and amylin. Poyner, D. Trends Pharmacol. Sci. (1995) [Pubmed]
  9. Evidence for cAMP-independent mechanisms mediating the effects of adrenomedullin, a new inotropic peptide. Szokodi, I., Kinnunen, P., Tavi, P., Weckström, M., Tóth, M., Ruskoaho, H. Circulation (1998) [Pubmed]
  10. Upregulation of ligand, receptor system, and amidating activity of adrenomedullin in left ventricular hypertrophy of severely hypertensive rats: effects of angiotensin-converting enzyme inhibitors and diuretic. Wang, X., Nishikimi, T., Akimoto, K., Tadokoro, K., Mori, Y., Minamino, N. J. Hypertens. (2003) [Pubmed]
  11. Pulmonary adrenomedullin counteracts deterioration of coronary flow and myocardial performance evoked by pulmonary endothelins in experimental acute respiratory distress syndrome. Stangl, K., Laule, M., Richter, C., Stangl, V., Koch, J., Göktas O, n.u.l.l., Baumann, G., Dschietzig, T. Crit. Care Med. (2001) [Pubmed]
  12. Adrenomedullin expression in a rat model of acute lung injury induced by hypoxia and LPS. Agorreta, J., Zulueta, J.J., Montuenga, L.M., Garayoa, M. Am. J. Physiol. Lung Cell Mol. Physiol. (2005) [Pubmed]
  13. Adrenomedullin and ocular inflammation in the rabbit. Clementi, G., Floriddia, M.L., Prato, A., Marino, A., Drago, F. Eur. J. Pharmacol. (2000) [Pubmed]
  14. Adrenomedullin receptor is found exclusively in noradrenaline-secreting cells of the rat adrenal medulla. Renshaw, D., Thomson, L.M., Michael, G.J., Carroll, M., Kapas, S., Hinson, J.P. J. Neurochem. (2000) [Pubmed]
  15. Upregulation of intracardiac adrenomedullin and its receptor system in rats with volume overload-induced cardiac hypertrophy. Yoshihara, F., Nishikimi, T., Okano, I., Hino, J., Horio, T., Tokudome, T., Suga, S., Matsuoka, H., Kangawa, K., Kawano, Y. Regul. Pept. (2005) [Pubmed]
  16. Characterization and effects on cAMP accumulation of adrenomedullin and calcitonin gene-related peptide (CGRP) receptors in dissociated rat spinal cord cell culture. Takhshid, M.A., Poyner, D.R., Chabot, J.G., Fournier, A., Ma, W., Zheng, W.H., Owji, A.A., Quirion, R. Br. J. Pharmacol. (2006) [Pubmed]
  17. Alterations of adrenomedullin and its receptor system components in calcified vascular smooth muscle cells. Pan, C.S., Qi, Y.F., Wang, S.H., Zhao, J., Bu, D.F., Li, G.Z., Tang, C.S. Regul. Pept. (2004) [Pubmed]
  18. The expression of mRNA for calcitonin receptor-like receptor/receptor-activity modifying proteins in rat peritoneal mast cells. Matsushima, M., Kitaichi, K., Tatsumi, Y., Hasegawa, T., Takagi, K. Eur. J. Pharmacol. (2003) [Pubmed]
  19. Estrogen and phytoestrogen regulate the mRNA expression of adrenomedullin and adrenomedullin receptor components in the rat uterus. Ikeda, K., Arao, Y., Otsuka, H., Kikuchi, A., Kayama, F. Mol. Cell. Endocrinol. (2004) [Pubmed]
  20. Role of cyclooxygenase in ventricular effects of adrenomedullin: is adrenomedullin a double-edged sword in sepsis? Mittra, S., Hyvelin, J.M., Shan, Q., Tang, F., Bourreau, J.P. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  21. Alterations of intrarenal adrenomedullin and its receptor system in heart failure rats. Yoshihara, F., Nishikimi, T., Okano, I., Horio, T., Yutani, C., Matsuo, H., Takishita, S., Ohe, T., Kangawa, K. Hypertension (2001) [Pubmed]
  22. Adrenomedullin induces heme oxygenase-1 gene expression and cGMP formation in rat vascular smooth muscle cells. Qi, Y.F., Dong, L.W., Pan, C.S., Zhang, J., Geng, B., Zhao, J., Tang, C.S. Peptides (2005) [Pubmed]
  23. The Adrenomedullin gene is a target for negative regulation by the Myc transcription complex. Wang, X., Peters, M.A., Utama, F.E., Wang, Y., Taparowsky, E.J. Mol. Endocrinol. (1999) [Pubmed]
  24. Induction of max by adrenomedullin and calcitonin gene-related peptide antagonizes endothelial apoptosis. Shichiri, M., Kato, H., Doi, M., Marumo, F., Hirata, Y. Mol. Endocrinol. (1999) [Pubmed]
  25. Adrenomedullin inhibits spontaneous and bradykinin-induced but not oxytocin- or prostaglandin F(2alpha)-induced periodic contraction of rat uterus. Yanagita, T., Yamamoto, R., Sugano, T., Kobayashi, H., Uezono, Y., Yokoo, H., Shiraishi, S., Minami, S.I., Wada, A. Br. J. Pharmacol. (2000) [Pubmed]
  26. Cerebral endothelial cells are a major source of adrenomedullin. Kis, B., Kaiya, H., Nishi, R., Deli, M.A., Abrahám, C.S., Yanagita, T., Isse, T., Gotoh, S., Kobayashi, H., Wada, A., Niwa, M., Kangawa, K., Greenwood, J., Yamashita, H., Ueta, Y. J. Neuroendocrinol. (2002) [Pubmed]
  27. Rat-2 fibroblasts express specific adrenomedullin receptors, but not calcitonin-gene-related-peptide receptors, which mediate increased intracellular cAMP and inhibit mitogen-activated protein kinase activity. Coppock, H.A., Owji, A.A., Austin, C., Upton, P.D., Jackson, M.L., Gardiner, J.V., Ghatei, M.A., Bloom, S.R., Smith, D.M. Biochem. J. (1999) [Pubmed]
  28. Antioxidant effect of adrenomedullin on angiotensin II-induced reactive oxygen species generation in vascular smooth muscle cells. Yoshimoto, T., Fukai, N., Sato, R., Sugiyama, T., Ozawa, N., Shichiri, M., Hirata, Y. Endocrinology (2004) [Pubmed]
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