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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Electromagnetic field-induced stimulation of Bruton's tyrosine kinase.

Here we present evidence that exposure of DT40 lymphoma B-cells to low energy electromagnetic fields (EMF) results in activation of phospholipase C-gamma 2 (PLC-gamma2), leading to increased inositol phospholipid turnover. PLC-gamma2 activation in EMF- stimulated cells is mediated by stimulation of the Bruton's tyrosine kinase (BTK), a member of the Src-related TEC family of protein tyrosine kinases, which acts downstream of LYN kinase and upstream of PLC-gamma2. B-cells rendered BTK-deficient by targeted disruption of the btk gene did not show enhanced PLC-gamma2 activation in response to EMF exposure. Introduction of the wild-type (but not a kinase domain mutant) human btk gene into BTK-deficient B-cells restored their EMF responsiveness. Thus, BTK exerts a pivotal and mandatory function in initiation of EMF-induced signaling cascades in B-cells.[1]

References

  1. Electromagnetic field-induced stimulation of Bruton's tyrosine kinase. Kristupaitis, D., Dibirdik, I., Vassilev, A., Mahajan, S., Kurosaki, T., Chu, A., Tuel-Ahlgren, L., Tuong, D., Pond, D., Luben, R., Uckun, F.M. J. Biol. Chem. (1998) [Pubmed]
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