Disease relevance of Electromagnetic Fields

• Here, we present evidence that exposure of DT40 lymphoma B cells to low energy electromagnetic field (EMF) results in a tyrosine kinase-dependent activation of phospholipase Cgamma2 (PLC-gamma2) leading to increased inositol phospholipid turnover [1].
• In conclusion, we have shown that electromagnetic fields stimulate bone resorption through an action on the osteoblast and, by abolishing the inhibitory effects of calcitonin, also restore the responsiveness of osteoclasts to divalent cations [2].
• Induction of tamoxifen resistance in breast cancer cells by ELF electromagnetic fields [3].
• Exposure of human lymphocyte cultures to a pulsing electromagnetic field (PEMF; 50 Hz, 1.05 mT) for various durations (24, 48 and 72 h) resulted in a statistically significant suppression of mitotic activity and a higher incidence of chromosomal aberrations [4].
• Exposure to pulsed electromagnetic field attenuated cortical ischemia edema on MRI at the most anterior coronal level by 65% (P < 0.001) [5].

Psychiatry related information on Electromagnetic Fields

• Electromagnetic field exposure may cause increased production of amyloid beta and eventually lead to Alzheimer's disease [6].
• Potential action of ultra-wideband (UWB) electromagnetic field pulses on effects of N(G)-nitro- L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthase (NOS), on nociception and locomotor activity was investigated in CF-1 mice [7].
• Brief, extracerebral applications of picotesla (pT) range flux intensity electromagnetic fields (EMFs) of low frequency have been shown efficacious in the treatment of motor and cognitive symptoms in MS implying that this treatment modality improves action potential transmission in demyelinating pathways [8].

High impact information on Electromagnetic Fields

• Ionic factors in release of 45Ca2+ from chicken cerebral tissue by electromagnetic fields [9].
• However, no significant effects of low-energy electromagnetic fields on tyrosine kinase activities or protein phosphorylation were observed [10].
• Transferrin binding to two human colon carcinoma cell lines: characterization and effect of 60-Hz electromagnetic fields [11].
• In this Letter we show that this is the case for a electromagnetic field mode in an optical cavity with a movable mirror in a thermal state [12].
• When the incident angle is larger than the critical value (theta> or =thetacr), despite an MeV electron being injected obliquely into the target, the high energy electron is decoupled from the bulk of the plasma and transported along the surface by the structured electron motion guided by the surface quasistatic electromagnetic field [13].

Chemical compound and disease context of Electromagnetic Fields

• Stimulation of Bruton's tyrosine kinase (BTK) and inositol 1,4,5-trisphosphate production in leukemia and lymphoma cells exposed to low energy electromagnetic fields [14].
• Neutropenia was marked after exposure to carbon disulphide, arsenic compounds, benzene and electromagnetic fields [15].

Biological context of Electromagnetic Fields

• We found no support for the hypothesis of an association between occupational exposure to electromagnetic fields and the risk of MS [16].
• The release kinetics of 5-FU from TMs was successfully analyzed by physiological modeling, which allows the prediction of intratumor drug concentrations during electromagnetic field exposure under various conditions [17].
• Exposure of xrs5 cells to 60 Hz ELF electromagnetic fields following irradiation can affect cell cycle distribution and transiently suppress apoptosis by decreasing the levels of caspase-3, p21, p53 and phospho-p53 and by increasing bcl-2 expression [18].
• Compared to the nonresistant cells not exposed to pulsing electromagnetic fields (PEMF) in ADR-free medium, their growth rates at ADR concentrations of 0.01 and 0.02 micrograms/ml, which were below IC50, were 83.0% and 61.8%, respectively [19].
• Ets1 oncogene induction by ELF-modulated 50 MHz radiofrequency electromagnetic field [20].

Anatomical context of Electromagnetic Fields

• Lyn and syk tyrosine kinases are not activated in B-lineage lymphoid cells exposed to low-energy electromagnetic fields [10].
• 1800 MHz electromagnetic field effects on melatonin release from isolated pineal glands [21].
• The present study describes the effect of low frequency, low energy, pulsing electromagnetic fields (PEMFs) on A2A adenosine receptors in human neutrophils [22].
• Osteocytes respond to induced shear by increasing connexin 43 (Cx43) levels, suggesting that they might be sensitive to physical stimuli like low-frequency electromagnetic fields (EMF) [23].
• Exposure to low-frequency electromagnetic fields does not alter HSP70 expression or HSF-HSE binding in HL60 cells [24].

Associations of Electromagnetic Fields with chemical compounds

• Electron-electron interaction in strong electromagnetic fields: the two-electron contribution to the ground-state energy in He-like uranium [25].
• Glucose is partitioned into an alkanethiol monolayer adsorbed on a silver film over nanosphere (AgFON) surface and thereby, it is preconcentrated within the 0-4 nm thick zone of electromagnetic field enhancement [26].
• That hypothesis specifically proposes that increased exposure to light at night and electromagnetic fields (EMF) reduce melatonin production [27].
• Increase in nitric oxide and cyclic GMP of rat cerebellum by radio frequency burst-type electromagnetic field radiation [28].
• In addition, we discuss the importance to the Raman cross sections of the local electromagnetic field enhancement due to the dielectric environment of the tyrosinate residues in the protein [29].

Gene context of Electromagnetic Fields

• Increased levels of inducible HSP70 in cells exposed to electromagnetic fields [30].
• ERK1/2 phosphorylation, induced by electromagnetic fields, diminishes during neoplastic transformation [31].
• Effect of electromagnetic fields on several CD markers and transcription and expression of CD4 [32].
• Results from these experiments indicate that the 24-hour exposure to 60 Hz electric, magnetic, or combined electromagnetic fields had no effect on IL-1 production [33].
• Extremely low frequency pulsed electromagnetic fields increase interleukin-2 (IL-2) utilization and IL-2 receptor expression in mitogen-stimulated human lymphocytes from old subjects [34].

Analytical, diagnostic and therapeutic context of Electromagnetic Fields

• Microdialysis assessment of 5-fluorouracil release from thermosensitive magnetoliposomes induced by an electromagnetic field in tumor-bearing mice [17].
• The effects of samarium-cobalt magnets and pulsed electromagnetic fields on tooth movement [35].
• Direct comparisons of R6G surface-enhanced Raman spectroscopy (SERS) signals between ordered nanocluster regions and amorphous Ag regions prepared under identical deposition conditions provide strong evidence of an electromagnetic field enhancement attributed to the unique nanocluster morphology [36].
• Group 1 served as untreated controls, group 2 was exposed to an electromagnetic field but received no additional treatment, and group 3 was exposed to electromagnetic radiation and treated with 3-mg/kg daily intraperitoneal injections of zinc sulfate [37].
• Theoretical studies of the kinetics of methane hydrate crystallization in external electromagnetic fields [38].

References