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Gene Review

PLCG2  -  phospholipase C, gamma 2...

Homo sapiens

Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, APLAID, FCAS3, PLC-IV, PLC-gamma-2, ...
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Disease relevance of PLCG2


High impact information on PLCG2


Biological context of PLCG2


Anatomical context of PLCG2


Associations of PLCG2 with chemical compounds


Physical interactions of PLCG2

  • Together, our results suggest a central role for the SH2(N) domain in directing PLC-gamma 2 into the close proximity of BCR signaling complex by its association with BLNK, whereby PLC-gamma 2 becomes tyrosine phosphorylated and thereby activated [18].

Enzymatic interactions of PLCG2


Regulatory relationships of PLCG2


Other interactions of PLCG2

  • In summary, this is the first report of a reconstitution of mammalian tyrosine kinase-linked effector activation in yeast cells and also the first demonstration of direct PLC gamma 2 activation by the proto-oncogene c-src [24].
  • PLC activity in homogenates from hPLC-gamma 2 overexpressing cells was increased as compared to control cells transfected with the vector lacking the hPLC-gamma 2 cDNA insert [25].
  • We conclude that both isoforms PLC-gamma 1 and PLC-gamma 2 are targets of the antigen receptor-associated protein tyrosine kinase [26].
  • After labelling the cells with [35S]methionine an increase of radioactive label in a protein migrating at 148 kDa could be detected in IFN-alpha-stimulated, hPLC-gamma 2 overexpressing cells [25].
  • A possible explanation for the SH2(N) requirement was provided by findings that this mutation abrogates the association of PLC-gamma 2 with an adaptor protein BLNK [18].

Analytical, diagnostic and therapeutic context of PLCG2


  1. Activation of human neutrophils by Mycobacterium tuberculosis H37Ra involves phospholipase C gamma 2, Shc adapter protein, and p38 mitogen-activated protein kinase. Perskvist, N., Zheng, L., Stendahl, O. J. Immunol. (2000) [Pubmed]
  2. Expression of enzymatically-active phospholipase Cgamma2 in E. coli. Ozdener, F., Kunapuli, S.P., Daniel, J.L. J. Biochem. Mol. Biol. (2002) [Pubmed]
  3. Electromagnetic field-induced stimulation of Bruton's tyrosine kinase. Kristupaitis, D., Dibirdik, I., Vassilev, A., Mahajan, S., Kurosaki, T., Chu, A., Tuel-Ahlgren, L., Tuong, D., Pond, D., Luben, R., Uckun, F.M. J. Biol. Chem. (1998) [Pubmed]
  4. Epstein-Barr virus protein LMP2A regulates reactivation from latency by negatively regulating tyrosine kinases involved in sIg-mediated signal transduction. Miller, C.L., Lee, J.H., Kieff, E., Burkhardt, A.L., Bolen, J.B., Longnecker, R. Infectious agents and disease. (1994) [Pubmed]
  5. Nuclear lipid signalling. Irvine, R.F. Nat. Rev. Mol. Cell Biol. (2003) [Pubmed]
  6. Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry. Yu, P., Constien, R., Dear, N., Katan, M., Hanke, P., Bunney, T.D., Kunder, S., Quintanilla-Martinez, L., Huffstadt, U., Schröder, A., Jones, N.P., Peters, T., Fuchs, H., de Angelis, M.H., Nehls, M., Grosse, J., Wabnitz, P., Meyer, T.P., Yasuda, K., Schiemann, M., Schneider-Fresenius, C., Jagla, W., Russ, A., Popp, A., Josephs, M., Marquardt, A., Laufs, J., Schmittwolf, C., Wagner, H., Pfeffer, K., Mudde, G.C. Immunity (2005) [Pubmed]
  7. Protein kinase C mu (PKC mu) associates with the B cell antigen receptor complex and regulates lymphocyte signaling. Sidorenko, S.P., Law, C.L., Klaus, S.J., Chandran, K.A., Takata, M., Kurosaki, T., Clark, E.A. Immunity (1996) [Pubmed]
  8. Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases. Miller, C.L., Burkhardt, A.L., Lee, J.H., Stealey, B., Longnecker, R., Bolen, J.B., Kieff, E. Immunity (1995) [Pubmed]
  9. Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C gamma 2. Ren, C.L., Morio, T., Fu, S.M., Geha, R.S. J. Exp. Med. (1994) [Pubmed]
  10. Mapping the gene that encodes phosphatidylinositol-specific phospholipase C-gamma 2 in the human and the mouse. Hernandez, D., Egan, S.E., Yulug, I.G., Fisher, E.M. Genomics (1994) [Pubmed]
  11. Phospholipase C gamma-2 (Plcg2) and phospholipase C gamma-1 (Plcg1) map to distinct regions in the human and mouse genomes. Argeson, A.C., Druck, T., Veronese, M.L., Knopf, J.L., Buchberg, A.M., Huebner, K., Siracusa, L.D. Genomics (1995) [Pubmed]
  12. Phosphatidylinositol 3-kinase regulates glycosylphosphatidylinositol hydrolysis through PLC-gamma(2) activation in erythropoietin-stimulated cells. Boudot, C., Kadri, Z., Petitfrère, E., Lambert, E., Chrétien, S., Mayeux, P., Haye, B., Billat, C. Cell. Signal. (2002) [Pubmed]
  13. Identification of radiation-specific responses from gene expression profile. Park, W.Y., Hwang, C.I., Im, C.N., Kang, M.J., Woo, J.H., Kim, J.H., Kim, Y.S., Kim, J.H., Kim, H., Kim, K.A., Yu, H.J., Lee, S.J., Lee, Y.S., Seo, J.S. Oncogene (2002) [Pubmed]
  14. Predominant expression and activation-induced tyrosine phosphorylation of phospholipase C-gamma 2 in B lymphocytes. Coggeshall, K.M., McHugh, J.C., Altman, A. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  15. Phenylarsine oxide inhibits tyrosine phosphorylation of phospholipase C gamma 2 in human platelets and phospholipase C gamma 1 in NIH-3T3 fibroblasts. Yanaga, F., Asselin, J., Schieven, G.L., Watson, S.P. FEBS Lett. (1995) [Pubmed]
  16. Signaling role for phospholipase C gamma 2 in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcR gamma chain and Fc gamma RIIA. Mangin, P., Yuan, Y., Goncalves, I., Eckly, A., Freund, M., Cazenave, J.P., Gachet, C., Jackson, S.P., Lanza, F. J. Biol. Chem. (2003) [Pubmed]
  17. Fc gamma receptor activation induces the tyrosine phosphorylation of both phospholipase C (PLC)-gamma 1 and PLC-gamma 2 in natural killer cells. Ting, A.T., Karnitz, L.M., Schoon, R.A., Abraham, R.T., Leibson, P.J. J. Exp. Med. (1992) [Pubmed]
  18. Cutting edge: association of phospholipase C-gamma 2 Src homology 2 domains with BLNK is critical for B cell antigen receptor signaling. Ishiai, M., Sugawara, H., Kurosaki, M., Kurosaki, T. J. Immunol. (1999) [Pubmed]
  19. Involvement of the Src kinase Lyn in phospholipase C-gamma 2 phosphorylation and phosphatidylinositol 3-kinase activation in Epo signalling. Boudot, C., Dassé, E., Lambert, E., Kadri, Z., Mayeux, P., Chrétien, S., Haye, B., Billat, C., Petitfrère, E. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  20. Thrombin activation of human platelets causes tyrosine phosphorylation of PLC-gamma 2. Tate, B.F., Rittenhouse, S.E. Biochim. Biophys. Acta (1993) [Pubmed]
  21. Ca2+ signalling mechanisms of the beta 2 integrin on neutrophils: involvement of phospholipase C gamma 2 and Ins(1,4,5)P3. Hellberg, C., Molony, L., Zheng, L., Andersson, T. Biochem. J. (1996) [Pubmed]
  22. Down-regulation of phospholipase C-gamma 1 during the differentiation of U937 cells. Lee, Y.H., Lee, H.J., Lee, S.J., Min, D.S., Baek, S.H., Kim, Y.S., Ryu, S.H., Suh, P.G. FEBS Lett. (1995) [Pubmed]
  23. Integrin alpha IIb beta 3-dependent calcium signals regulate platelet-fibrinogen interactions under flow. Involvement of phospholipase C gamma 2. Goncalves, I., Hughan, S.C., Schoenwaelder, S.M., Yap, C.L., Yuan, Y., Jackson, S.P. J. Biol. Chem. (2003) [Pubmed]
  24. Activation of phospholipase C gamma in Schizosaccharomyces pombe by coexpression of receptor or nonreceptor tyrosine kinases. Arkinstall, S., Payton, M., Maundrell, K. Mol. Cell. Biol. (1995) [Pubmed]
  25. Inducible expression of human phospholipase C-gamma 2 and its activation by platelet-derived growth factor B-chain homodimer and platelet-derived growth factor A-chain homodimer in transfected NIH 3T3 fibroblasts. Totzke, F., Marmé, D., Hug, H. Eur. J. Biochem. (1992) [Pubmed]
  26. Phospholipase C-gamma 1 and phospholipase C-gamma 2 are substrates of the B cell antigen receptor associated protein tyrosine kinase. Roifman, C.M., Wang, G. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  27. Membrane immunoglobulin and its accomplices: new lessons from an old receptor. Cambier, J.C., Campbell, K.S. FASEB J. (1992) [Pubmed]
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