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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Central distribution and function of 5-HT6 receptor subtype in the rat brain.

The purpose of the present study was to elucidate the distribution of 5-HT6 receptor mRNA and possible physiological functions of the 5-HT6 receptor subtype using antisense oligonucleotides (AOs) in rats. Continuous intracerebroventricular injection of AOs caused a 30% reduction in the number of [3H]-lysergic acid diethylamide binding sites. Conditioned fear stress-induced increase in 5-HT release from the prefrontal cortex was significantly inhibited by treatment with AOs. The present study suggests that 5-HT6 receptors may be functionally expressed in the brain, where one of the functions appears to be in the mediation of certain anxiety disorders.[1]


  1. Central distribution and function of 5-HT6 receptor subtype in the rat brain. Yoshioka, M., Matsumoto, M., Togashi, H., Mori, K., Saito, H. Life Sci. (1998) [Pubmed]
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