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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Neonatal responsiveness to alcohol odor and infant alcohol intake as a function of alcohol experience during late gestation.

It has been previously suggested that maternal alcohol intoxication during the last days of pregnancy promotes fetal experiences that include chemosensory processing of the drug. In this study pregnant Wistar-derived rats were administered saline or one of two alcohol doses (1 or 2 g/kg) during gestational days 17-20. Immediately after birth, pups were tested in regard to motor-eliciting properties of the odor of amniotic fluid or alcohol, or of these stimuli presented as a configuration. Saline controls showed significantly shorter duration of overall motor activity and head movements when stimulated with the biological cue (amniotic fluid) than when exposed to a novel stimulus (ethanol alone or configured with the amniotic fluid). The opposite pattern was found in pups with prenatal experience with the higher alcohol dose. In a second experiment, the impact of similar alcohol treatments on infant consumption of different tastants, including alcohol and a configuration of sucrose and quinine, was tested. This configuration appears to mimic psychophysical properties of ethanol. Consumption of water, sucrose, or quinine was unaffected by the prenatal status of the subjects. Antenatal alcohol experience with the lower alcohol dose (1 g/kg) increased both alcohol and sucrose-quinine consumption. The 2 g/kg alcohol animals also ingested more sucrose-quinine relative to saline controls. As a whole, the results confirm the hypothesis that an intrauterine alcohol sensory memory selectively affects neonatal recognition of the alcohol's olfactory attributes and infant intake of either alcohol or solutions that share certain sensory equivalence with this psychopharmacological agent.[1]

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