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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Case of the month: March 1998--48 year old man with back pain and weakness.

A 48 year old man with long history of end stage renal disease (ESRD) and secondary hyperparathyroidism presented with back pain and incontinence. MRI and CT showed T2 expansion with bony destruction and spinal cord compression. Other vertebral bodies showed destructive lesions as well. Microscopic examination showed a brown tumor composed of multinucleated giant cells and bone uninvolved by tumor showed "tunneling" resorption. Brown tumors are an exaggerated form of "local" osteitis fibrosa cystica in patients with ESRD and secondary hyperparathyroidism, but spinal cord compression is rare.[1]


  1. Case of the month: March 1998--48 year old man with back pain and weakness. Mourelatus, Z., Goldberg, H., Sinson, G., Quan, D., Lavi, E. Brain Pathol. (1998) [Pubmed]
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