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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Atypical stiff-person syndrome with spinal MRI findings, amphiphysin autoantibodies, and immunosuppression.

In an atypical case of stiff-person syndrome (SPS), spinal T2-weighted MRI revealed a hyperintense lesion extending from C2 to C7 that corresponded with the clinical symptoms and signs. CSF showed lymphocytic pleocytosis and oligoclonal bands. Amphiphysin autoantibodies were detected in serum and CSF; however, unlike other reported cases, no malignancy occurred during a 3-year observation period. Methylprednisolone and cyclophosphamide pulse therapy led to a marked reduction of symptoms.[1]

References

  1. Atypical stiff-person syndrome with spinal MRI findings, amphiphysin autoantibodies, and immunosuppression. Schmierer, K., Valdueza, J.M., Bender, A., DeCamilli, P., David, C., Solimena, M., Zschenderlein, R. Neurology (1998) [Pubmed]
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