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MeSH Review

Stiff-Person Syndrome

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Disease relevance of Stiff-Person Syndrome


High impact information on Stiff-Person Syndrome


Chemical compound and disease context of Stiff-Person Syndrome


Biological context of Stiff-Person Syndrome


Anatomical context of Stiff-Person Syndrome


Gene context of Stiff-Person Syndrome


Analytical, diagnostic and therapeutic context of Stiff-Person Syndrome


  1. Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome. Solimena, M., Folli, F., Aparisi, R., Pozza, G., De Camilli, P. N. Engl. J. Med. (1990) [Pubmed]
  2. Autoantibodies to glutamic acid decarboxylase in a patient with stiff-man syndrome, epilepsy, and type I diabetes mellitus. Solimena, M., Folli, F., Denis-Donini, S., Comi, G.C., Pozza, G., De Camilli, P., Vicari, A.M. N. Engl. J. Med. (1988) [Pubmed]
  3. Rhabdomyolysis and paraneoplastic stiff-man syndrome with amphiphysin autoimmunity. Petzold, G.C., Marcucci, M., Butler, M.H., van Landeghem, F.K., Einhäupl, K.M., Solimena, M., Valdueza, J.M., De Camilli, P. Ann. Neurol. (2004) [Pubmed]
  4. Two amino acids in glutamic acid decarboxylase act in concert for maintenance of conformational determinants recognised by Type I diabetic autoantibodies. Tree, T.I., Morgenthaler, N.G., Duhindan, N., Hicks, K.E., Madec, A.M., Scherbaum, W.A., Banga, J.P. Diabetologia (2000) [Pubmed]
  5. Autoantibodies against a novel 51 kDa islet antigen and glutamate decarboxylase isoforms in autoimmune polyendocrine syndrome type I. Velloso, L.A., Winqvist, O., Gustafsson, J., Kämpe, O., Karlsson, F.A. Diabetologia (1994) [Pubmed]
  6. High-dose intravenous immune globulin for stiff-person syndrome. Dalakas, M.C., Fujii, M., Li, M., Lutfi, B., Kyhos, J., McElroy, B. N. Engl. J. Med. (2001) [Pubmed]
  7. Resolution of stiff-man syndrome with cortisol replacement in a patient with deficiencies of ACTH, growth hormone, and prolactin. George, T.M., Burke, J.M., Sobotka, P.A., Greenberg, H.S., Vinik, A.I. N. Engl. J. Med. (1984) [Pubmed]
  8. The clinical significance of an autoimmune response against glutamic acid decarboxylase. Ellis, T.M., Atkinson, M.A. Nat. Med. (1996) [Pubmed]
  9. Stiff-man syndrome and clonazepam. Westblom, U. JAMA (1977) [Pubmed]
  10. Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus. Kim, J., Namchuk, M., Bugawan, T., Fu, Q., Jaffe, M., Shi, Y., Aanstoot, H.J., Turck, C.W., Erlich, H., Lennon, V., Baekkeskov, S. J. Exp. Med. (1994) [Pubmed]
  11. Improvement of stiff-man syndrome with vigabatrin. Vermeij, F.H., van Doorn, P.A., Busch, H.F. Lancet (1996) [Pubmed]
  12. Baclofen in the treatment of stiff-man syndrome. Miller, F., Korsvik, H. Ann. Neurol. (1981) [Pubmed]
  13. A pharmacologic study of the stiff-man syndrome. Correlation of clinical symptoms with urinary 3-methoxy-4-hydroxy-phenyl glycol excretion. Schmidt, R.T., Stahl, S.M., Spehlmann, R. Neurology (1975) [Pubmed]
  14. Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of ranvier in brain and around T tubules in skeletal muscle. Butler, M.H., David, C., Ochoa, G.C., Freyberg, Z., Daniell, L., Grabs, D., Cremona, O., De Camilli, P. J. Cell Biol. (1997) [Pubmed]
  15. Primary structure of human amphiphysin, the dominant autoantigen of paraneoplastic stiff-man syndrome, and mapping of its gene (AMPH) to chromosome 7p13-p14. Yamamoto, R., Li, X., Winter, S., Francke, U., Kilimann, M.W. Hum. Mol. Genet. (1995) [Pubmed]
  16. Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase. Hiemstra, H.S., Schloot, N.C., van Veelen, P.A., Willemen, S.J., Franken, K.L., van Rood, J.J., de Vries, R.R., Chaudhuri, A., Behan, P.O., Drijfhout, J.W., Roep, B.O. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  17. Cytoplasmic islet cell antibodies recognize distinct islet antigens in IDDM but not in stiff man syndrome. Richter, W., Seissler, J., Northemann, W., Wolfahrt, S., Meinck, H.M., Scherbaum, W.A. Diabetes (1993) [Pubmed]
  18. Actin cytoskeleton and budding pattern are altered in the yeast rvs161 mutant: the Rvs161 protein shares common domains with the brain protein amphiphysin. Sivadon, P., Bauer, F., Aigle, M., Crouzet, M. Mol. Gen. Genet. (1995) [Pubmed]
  19. Stiff-man syndrome associated with antecedent myasthenia gravis and organ-specific autoimmunopathy. Aso, Y., Sato, A., Narimatsu, M., Takiguchi, Y., Yamaguchi, Y., Inukai, T., Takemura, Y. Intern. Med. (1997) [Pubmed]
  20. Immunohistochemical differentiation of monoclonal GAD antibodies recognizing linear or conformational epitope regions. Augstein, P., Ziegler, B., Schlosser, M., Flassig, S., Strebelow, M., Ziegler, M. Pancreas (1997) [Pubmed]
  21. Autoimmunity to gephyrin in Stiff-Man syndrome. Butler, M.H., Hayashi, A., Ohkoshi, N., Villmann, C., Becker, C.M., Feng, G., De Camilli, P., Solimena, M. Neuron (2000) [Pubmed]
  22. Distinct antigenic features of linear epitopes at the N-terminus and C-terminus of 65 kDa glutamic acid decarboxylase (GAD65): implications for autoantigen modification during pathogenesis. Al-Bukhari, T.A., Radford, P.M., Bouras, G., Davenport, C., Trigwell, S.M., Bottazzo, G.F., Lai, M., Schwartz, H.L., Tighe, P.J., Todd, I. Clin. Exp. Immunol. (2002) [Pubmed]
  23. Analysis of GAD65 autoantibodies in Stiff-Person syndrome patients. Raju, R., Foote, J., Banga, J.P., Hall, T.R., Padoa, C.J., Dalakas, M.C., Ortqvist, E., Hampe, C.S. J. Immunol. (2005) [Pubmed]
  24. Association of GAD-65, but not of GAD-67, with the Golgi complex of transfected Chinese hamster ovary cells mediated by the N-terminal region. Solimena, M., Aggujaro, D., Muntzel, C., Dirkx, R., Butler, M., De Camilli, P., Hayday, A. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  25. High level of concordance between assays for glutamic acid decarboxylase antibodies. The First International Glutamic Acid Decarboxylase Antibody Workshop. Schmidli, R.S., Colman, P.G., Bonifacio, E., Bottazzo, G.F., Harrison, L.C. Diabetes (1994) [Pubmed]
  26. Atypical stiff-person syndrome with spinal MRI findings, amphiphysin autoantibodies, and immunosuppression. Schmierer, K., Valdueza, J.M., Bender, A., DeCamilli, P., David, C., Solimena, M., Zschenderlein, R. Neurology (1998) [Pubmed]
  27. Vaccination against herpes zoster, small RNA against ALS and IgG antibodies in stiff-person syndrome. Strupp, M. J. Neurol. (2005) [Pubmed]
  28. Radioimmunoassay for glutamic acid decarboxylase (GAD65) autoantibodies as a diagnostic aid for stiff-man syndrome and a correlate of susceptibility to type 1 diabetes mellitus. Walikonis, J.E., Lennon, V.A. Mayo Clin. Proc. (1998) [Pubmed]
  29. Sporadic Stiffman syndrome in a young girl. Udani, V.P., Dharnidharka, V.R., Gajendragadkar, A.R., Udani, S.V. Pediatric neurology. (1997) [Pubmed]
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