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Gene Review

AMPH  -  amphiphysin

Homo sapiens

Synonyms: AMPH1, Amphiphysin
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Disease relevance of AMPH


Psychiatry related information on AMPH

  • Periadolescent (PND 33-43) and Adult (PND>60) mice of both sexes were injected with d-amphetamine (AMPH, 0, 2, or 10 mg/kg i.p.) and immediately faced with a mild psychological stress experience, i.e. placement in a novel environment [5].
  • AMT may be important in the low dose effects of AMPH such as increased locomotor activity in rodents and stimulant activity in man [6].
  • Finally, the possibility that the AMPH cue may generate false positives in screening for drug abuse potential needs to be evaluated [7].
  • Both TRH and low amph. increased grooming (perhaps simply by increasing wakefulness), but TRH failed to increase sniffing, a cardinal feature of ampha.-induced excitement [8].

High impact information on AMPH


Chemical compound and disease context of AMPH


Biological context of AMPH


Anatomical context of AMPH


Associations of AMPH with chemical compounds

  • The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity [2].
  • We describe here in detail the procedure of the dynamin GTPase assay and the results demonstrating stimulatory effect of amphiphysin on dynamin GTPase activity, which is highly dependent on the liposome size [19].
  • Using event-related functional magnetic resonance imaging (fMRI), we conducted a within-subject, double-blind, placebo (PLAC)-controlled study of the effects of oral dextroamphetamine (AMPH, 0.25 mg/kg) treatment on brain activity and affect during incentive processing [23].
  • Using positron emission tomography (PET), we correlated the change in endogenous dopamine concentrations following dextroamphetamine (AMPH) administration with the associated hedonic response in human subjects and compared the strength of this correlation across striatal subregions [22].
  • Subjects with higher cortisol responses to AMPH also reported more positive subjective drug effects than subjects with lower cortisol responses; no association was observed between cortisol levels and negative drug effects [24].

Physical interactions of AMPH


Enzymatic interactions of AMPH


Regulatory relationships of AMPH

  • There was a highly significant (P less than .001; slope = 1.2) linear correlation between the AMT-inhibiting potencies of AMPH analogs and their potencies in stimulating locomotor activity in rodents [6].

Other interactions of AMPH

  • We have precisely mapped the target peptides on human synaptojanin that are recognized by the SH3 domains of endophilins and amphiphysin and proven that they are distinct [2].
  • The elucidation of clathrin as a splice-specific binding partner for amphiphysin II begins to address the potential functional role(s) for the multiple amphiphysin II splice variants and further supports an important function for clathrin-amphiphysin interactions in protein targeting during endocytosis [29].
  • In addition to a single LLDLD-based, type I clathrin-binding sequence, both amphiphysin and epsin contain a second, distinct sequence that is also capable of binding to clathrin directly [30].
  • Bin2 formed a stable complex in cells with Bin1, but not with amphiphysin, in a BAR domain-dependent manner [31].
  • Finally, transient overexpression of the specific dominant-negative inhibitors of clathrin-mediated endocytosis, the SH3 domain of amphiphysin and the C-terminal domain of AP180, potently inhibited internalization of HRV2 [32].

Analytical, diagnostic and therapeutic context of AMPH


  1. Primary structure of human amphiphysin, the dominant autoantigen of paraneoplastic stiff-man syndrome, and mapping of its gene (AMPH) to chromosome 7p13-p14. Yamamoto, R., Li, X., Winter, S., Francke, U., Kilimann, M.W. Hum. Mol. Genet. (1995) [Pubmed]
  2. The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity. Cestra, G., Castagnoli, L., Dente, L., Minenkova, O., Petrelli, A., Migone, N., Hoffmüller, U., Schneider-Mergener, J., Cesareni, G. J. Biol. Chem. (1999) [Pubmed]
  3. The synaptic vesicle-associated protein amphiphysin is the 128-kD autoantigen of Stiff-Man syndrome with breast cancer. De Camilli, P., Thomas, A., Cofiell, R., Folli, F., Lichte, B., Piccolo, G., Meinck, H.M., Austoni, M., Fassetta, G., Bottazzo, G. J. Exp. Med. (1993) [Pubmed]
  4. Phosphorylation of amphiphysin I by minibrain kinase/dual-specificity tyrosine phosphorylation-regulated kinase, a kinase implicated in Down syndrome. Murakami, N., Xie, W., Lu, R.C., Chen-Hwang, M.C., Wieraszko, A., Hwang, Y.W. J. Biol. Chem. (2006) [Pubmed]
  5. A unique hormonal and behavioral hyporesponsivity to both forced novelty and d-amphetamine in periadolescent mice. Adriani, W., Laviola, G. Neuropharmacology (2000) [Pubmed]
  6. Interactions of [3H]amphetamine with rat brain synaptosomes. II. Active transport. Zaczek, R., Culp, S., De Souza, E.B. J. Pharmacol. Exp. Ther. (1991) [Pubmed]
  7. Discriminative stimulus properties of amphetamine, cathinone, and related agents. Goudie, A.J. NIDA Res. Monogr. (1991) [Pubmed]
  8. Thyrotropin-releasing hormone and amphetamine produce different patterns of behavioral excitation in rats. Ervin, G.N., Schmitz, S.A., Nemeroff, C.B., Prange, A.J. Eur. J. Pharmacol. (1981) [Pubmed]
  9. BIN1 is a novel MYC-interacting protein with features of a tumour suppressor. Sakamuro, D., Elliott, K.J., Wechsler-Reya, R., Prendergast, G.C. Nat. Genet. (1996) [Pubmed]
  10. Synaptic vesicle endocytosis impaired by disruption of dynamin-SH3 domain interactions. Shupliakov, O., Löw, P., Grabs, D., Gad, H., Chen, H., David, C., Takei, K., De Camilli, P., Brodin, L. Science (1997) [Pubmed]
  11. The amphiphysin family of proteins and their role in endocytosis at the synapse. Wigge, P., McMahon, H.T. Trends Neurosci. (1998) [Pubmed]
  12. A randomized, double-blind comparative trial evaluating the safety of liposomal amphotericin B versus amphotericin B lipid complex in the empirical treatment of febrile neutropenia. L Amph/ABLC Collaborative Study Group. Wingard, J.R., White, M.H., Anaissie, E., Raffalli, J., Goodman, J., Arrieta, A. Clin. Infect. Dis. (2000) [Pubmed]
  13. Enhancement of platinum-drug cytotoxicity in a human head and neck squamous cell carcinoma line and its platinum-resistant variant by liposomal amphotericin B and phospholipase A2-II. Ferguson, P.J., Currie, C., Vincent, M.D. Drug Metab. Dispos. (1999) [Pubmed]
  14. Pharmacokinetics of antifungal agents. Fabris, A., Pellanda, M.V., Gardin, C., Contestabile, A., Bolzonella, R. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. (1993) [Pubmed]
  15. Functional partnership between amphiphysin and dynamin in clathrin-mediated endocytosis. Takei, K., Slepnev, V.I., Haucke, V., De Camilli, P. Nat. Cell Biol. (1999) [Pubmed]
  16. Identification and characterization of a nerve terminal-enriched amphiphysin isoform. Ramjaun, A.R., Micheva, K.D., Bouchelet, I., McPherson, P.S. J. Biol. Chem. (1997) [Pubmed]
  17. Novel splice variants of amphiphysin I are expressed in retina. Terada, Y., Tsutsui, K., Sano, K., Hosoya, O., Ohtsuki, H., Tokunaga, A., Tsutsui, K. FEBS Lett. (2002) [Pubmed]
  18. Acute effects of d-amphetamine during the follicular and luteal phases of the menstrual cycle in women. Justice, A.J., de Wit, H. Psychopharmacology (Berl.) (1999) [Pubmed]
  19. Stimulation of dynamin GTPase activity by amphiphysin. Yoshida, Y., Takei, K. Meth. Enzymol. (2005) [Pubmed]
  20. Expression of amphiphysin I, an autoantigen of paraneoplastic neurological syndromes, in breast cancer. Floyd, S., Butler, M.H., Cremona, O., David, C., Freyberg, Z., Zhang, X., Solimena, M., Tokunaga, A., Ishizu, H., Tsutsui, K., De Camilli, P. Mol. Med. (1998) [Pubmed]
  21. Autoimmunity in stiff-Man syndrome with breast cancer is targeted to the C-terminal region of human amphiphysin, a protein similar to the yeast proteins, Rvs167 and Rvs161. David, C., Solimena, M., De Camilli, P. FEBS Lett. (1994) [Pubmed]
  22. Amphetamine-induced dopamine release in human ventral striatum correlates with euphoria. Drevets, W.C., Gautier, C., Price, J.C., Kupfer, D.J., Kinahan, P.E., Grace, A.A., Price, J.L., Mathis, C.A. Biol. Psychiatry (2001) [Pubmed]
  23. Amphetamine modulates human incentive processing. Knutson, B., Bjork, J.M., Fong, G.W., Hommer, D., Mattay, V.S., Weinberger, D.R. Neuron (2004) [Pubmed]
  24. Relationships among ventral striatal dopamine release, cortisol secretion, and subjective responses to amphetamine. Oswald, L.M., Wong, D.F., McCaul, M., Zhou, Y., Kuwabara, H., Choi, L., Brasic, J., Wand, G.S. Neuropsychopharmacology (2005) [Pubmed]
  25. The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. Grabs, D., Slepnev, V.I., Songyang, Z., David, C., Lynch, M., Cantley, L.C., De Camilli, P. J. Biol. Chem. (1997) [Pubmed]
  26. A novel mode of action of an ArfGAP, AMAP2/PAG3/Papa lpha, in Arf6 function. Hashimoto, S., Hashimoto, A., Yamada, A., Kojima, C., Yamamoto, H., Tsutsumi, T., Higashi, M., Mizoguchi, A., Yagi, R., Sabe, H. J. Biol. Chem. (2004) [Pubmed]
  27. Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2. Floyd, S.R., Porro, E.B., Slepnev, V.I., Ochoa, G.C., Tsai, L.H., De Camilli, P. J. Biol. Chem. (2001) [Pubmed]
  28. Nerve growth factor-induced phosphorylation of amphiphysin-1 by casein kinase 2 regulates clathrin-amphiphysin interactions. Döring, M., Loos, A., Schrader, N., Pfander, B., Bauerfeind, R. J. Neurochem. (2006) [Pubmed]
  29. Multiple amphiphysin II splice variants display differential clathrin binding: identification of two distinct clathrin-binding sites. Ramjaun, A.R., McPherson, P.S. J. Neurochem. (1998) [Pubmed]
  30. Interaction of two structurally distinct sequence types with the clathrin terminal domain beta-propeller. Drake, M.T., Traub, L.M. J. Biol. Chem. (2001) [Pubmed]
  31. Bin2, a functionally nonredundant member of the BAR adaptor gene family. Ge, K., Prendergast, G.C. Genomics (2000) [Pubmed]
  32. Human rhinovirus type 2 is internalized by clathrin-mediated endocytosis. Snyers, L., Zwickl, H., Blaas, D. J. Virol. (2003) [Pubmed]
  33. Prenatal cadmium and ethanol increase amphetamine-evoked dopamine release in rat striatum. Nowak, P., Dabrowska, J., Bortel, A., Izabela, B., Kostrzewa, R.M., Brus, R. Neurotoxicology and teratology (2006) [Pubmed]
  34. Investigations on the interaction between cyproheptadine and amphetamine. Cenajek, D., Chodera, A., Godlewski, J., Wójciak, Z. Acta physiologica Polonica. (1980) [Pubmed]
  35. Inhibition of receptor-mediated endocytosis by the amphiphysin SH3 domain. Wigge, P., Vallis, Y., McMahon, H.T. Curr. Biol. (1997) [Pubmed]
  36. cDNA cloning of a novel amphiphysin isoform and tissue-specific expression of its multiple splice variants. Tsutsui, K., Maeda, Y., Tsutsui, K., Seki, S., Tokunaga, A. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  37. Antiamphiphysin antibodies with small-cell lung carcinoma and paraneoplastic encephalomyelitis. Dropcho, E.J. Ann. Neurol. (1996) [Pubmed]
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