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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A viral mechanism for inhibition of the cellular phosphatase calcineurin.

The transcription factor NFAT (nuclear factor of activated T cells) controls the expression of many immunomodulatory proteins. African swine fever virus inhibits proinflammatory cytokine expression in infected macrophages, and a viral protein A238L was found to display the activity of the immunosuppressive drug cyclosporin A by inhibiting NFAT-regulated gene transcription in vivo. This it does by binding the catalytic subunit of calcineurin and inhibiting calcineurin phosphatase activity.[1]

References

  1. A viral mechanism for inhibition of the cellular phosphatase calcineurin. Miskin, J.E., Abrams, C.C., Goatley, L.C., Dixon, L.K. Science (1998) [Pubmed]
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