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Gene Review:

NFAT - nuclear factor of activated T-cells

Sus scrofa

Matsuo, K. et al., Miskin, J.E. et al., Lin, C.C. et al., Mehrotra, S. et al.

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Disease relevance of NFAT

African swine fever virus inhibits proinflammatory cytokine expression in infected macrophages, and a viral protein A238L was found to display the activity of the immunosuppressive drug cyclosporin A by inhibiting NFAT-regulated gene transcription in vivo [1].
Moreover, in Fos(-/-) precursors gene transfer of an active form of NFAT restored transcription of osteoclast-specific genes in the presence of receptor activator of the NF-kappaB ligand (RANKL), rescuing bone resorption [2].

High impact information on NFAT

The transcription factor NFAT (nuclear factor of activated T cells) controls the expression of many immunomodulatory proteins [1].
6. Stimulation of transfected HEK293 as well as COS-7 cells with noradrenaline, in dual luciferase assay, we found significant (P</=0.05) elevation of serum response element (SRE) and activator protein-1 (AP-1), while nuclear factor of kappaB cells (NFkappaB) and nuclear factor of activated T-cells (NFAT) remained unchanged [3].

Biological context of NFAT

STUDY OBJECTIVES: The calcineurin-nuclear factor of activated T-cell (NFAT) signal transduction pathway regulates the expression of a plethora of genes in the myocardium [4].

Analytical, diagnostic and therapeutic context of NFAT

The electrophoresis mobility shift assay further demonstrated that nuclear extracts from AF tissue had a significantly larger binding capacity for NFAT-specific oligonucleotide probes [4].

References

A viral mechanism for inhibition of the cellular phosphatase calcineurin. Miskin, J.E., Abrams, C.C., Goatley, L.C., Dixon, L.K. Science (1998) [Pubmed]
Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos. Matsuo, K., Galson, D.L., Zhao, C., Peng, L., Laplace, C., Wang, K.Z., Bachler, M.A., Amano, H., Aburatani, H., Ishikawa, H., Wagner, E.F. J. Biol. Chem. (2004) [Pubmed]
Cloning of the porcine alpha(2B)-adrenoceptor: Tissue distribution and pharmacological characterization. Mehrotra, S., Zhang, J., Teunissen, A.W., Saxena, P.R., Vandenbrink, A.M., Walther, T., Sharma, H.S. Eur. J. Pharmacol. (2006) [Pubmed]
Activation of the calcineurin-nuclear factor of activated T-cell signal transduction pathway in atrial fibrillation. Lin, C.C., Lin, J.L., Lin, C.S., Tsai, M.C., Su, M.J., Lai, L.P., Huang, S.K. Chest (2004) [Pubmed]

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