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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Formation of a spherical multicellular aggregate (spheroid) of animal cells in the pores of polyurethane foam as a cell culture substratum and its application to a hybrid artificial liver.

Monkey kidney cells (Vero), human embryonic kidney cells (293), human liver cells ( PLC/PRF/5), and primary rat, dog, and porcine hepatocytes formed spherical multicellular aggregates (spheroids) in the pores of polyurethane foam which was used as a cell culture substratum. These spheroids of various cell types express high cell activity for a long period. A practical hybrid artificial live support system composed of a multi-capillary polyurethane foam packed-bed type cell culture module including primary hepatocyte spheroids was developed. The success of the system is indicated by an 80% recovery rate in hepatic failure rats which died in control experiments.[1]

References

  1. Formation of a spherical multicellular aggregate (spheroid) of animal cells in the pores of polyurethane foam as a cell culture substratum and its application to a hybrid artificial liver. Ijima, H., Nakazawa, K., Mizumoto, H., Matsushita, T., Funatsu, K. Journal of biomaterials science. Polymer edition. (1998) [Pubmed]
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