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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Intracellular calcium suppresses mechano-electrical transduction current in chick cochlear hair cells.

Intracellular calcium concentration ([Ca2+]i) was elevated by photolysis of the caged calcium compound, Nitr-5, and by use of the intrapipette perfusion technique in hair cells dissociated from the chick cochlea. An increase in [Ca2+]i induced an outward-going current at a membrane potential of -40 mV, as recorded with an intracellular medium of 160 mM KCl. This current was carried by the Ca2+-activated K+ current. In contrast, an increase of [Ca2+]i induced an inward-going current at -50 mV with a 160 mM CsCl-based intracellular medium. This inward-going current was carried by the Ca2+-activated non-selective cation current. The amplitude of the mechano-electrical transduction current was suppressed by the increase of [Ca2+]i, achieved both by photolysis and by use of the intrapipette perfusion method.[1]

References

  1. Intracellular calcium suppresses mechano-electrical transduction current in chick cochlear hair cells. Kimitsuki, T., Taira, T., Komune, S., Komiyama, S. ORL J. Otorhinolaryngol. Relat. Spec. (1998) [Pubmed]
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