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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Increased capacity for interleukin-2 synthesis parallels disease progression in mice infected with Leishmania major.

Lymph node cells of BALB/c mice with progressive leishmaniasis produced sixfold more interleukin-2 (IL-2) in culture than those of healing C57BL/6 mice. IL-2 synthesis also increased in C57BL/6 mice made susceptible by IL-12 or gamma interferon deficiency. However, IL-2 mRNA levels in vivo did not reflect IL-2 production in vitro. Because IL-2 contributes to the pathogenesis of progressive leishmaniasis, the functional significance of these findings should be further explored.[1]

References

  1. Increased capacity for interleukin-2 synthesis parallels disease progression in mice infected with Leishmania major. Heinzel, F.P., Rerko, R.M., Hujer, A.M., Maier, R.A. Infect. Immun. (1998) [Pubmed]
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