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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The effects of glucocorticoids (dexamethasone) on insulin-like growth factor-I, IGF-binding proteins, and growth in chickens.

The effect of glucocorticoids (dexamethasone) on circulating concentrations of insulin-like growth factor (IGF)-I and IGF binding proteins (IGFBPs) was examined in young (2-week-old) chickens. Increasing dosages (6, 60, and 600 microg/kg) of dexamethasone resulted in progressive growth retardation as evidenced by decreased body-weight gain, reduced bone growth, and breast muscle weights, together with immunosuppression as indicated by decreased thymus and bursa weights. Plasma concentrations of IGF-I were progressively reduced with increased doses of dexamethasone. There were no changes in circulating IGFBPs except on Day 7 when binding activity of the 36-kDa IGFBP was increased by dexamethasone (6 microg/kg). It is speculated that similarities exist between the 36-kDa IGFBP and the mammalian IGFBP-1 based on the response to dexamethasone treatment.[1]


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