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Gene Review

IGFBP1  -  insulin-like growth factor binding protein 1

Gallus gallus

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Disease relevance of IGFBP1

  • CONCLUSIONS: The elevated IGFBP levels and reduced IGF-1 levels on days 5 and 6 of incubation are congruent with an overall reduction in the bioavailability of IGF-1 during this period and correlate with the decreased embryo weight observed in the alcohol-treated embryos [1].

High impact information on IGFBP1

  • Pelvic cartilages secreted in vitro both IGF-I and IGF-II and a 32-34 kD IGFBP [2].
  • In separate experiments, serum-free medium conditioned by chick pelvic cartilages for 72 h was assayed for IGF-II by radioreceptorassay, IGF-I by radioimmunoassay, and IGFBP by western ligand analysis [2].
  • The decrease in circulating concentrations of IGF-I appeared to be inversely related to the initial increase in the binding activity of the 30-kDa IGFBP on Day 3 (5% and 10% protein) and to the increased binding activity of the 40-kDa IGFBP on Days 3 and 7 (10% protein) [3].
  • There were no changes in circulating IGFBPs except on Day 7 when binding activity of the 36-kDa IGFBP was increased by dexamethasone (6 microg/kg) [4].
  • IGFBP-28 transiently increased with fasting and was inversely related to blood glucose and insulin levels, suggesting that it is equivalent to mammalian IGFBP-1 [5].

Biological context of IGFBP1


Physical interactions of IGFBP1

  • The 30-kDa IGFBP was most affected by feed restriction with binding activity of this IGFBP increased by 2 days of feed restriction irrespective of the degree of feed deprivation [7].

Regulatory relationships of IGFBP1

  • IGF-I and IGFBP concentrations in the plasma of young broiler chickens were influenced by nutritional state but IGF-II concentrations were not [8].

Other interactions of IGFBP1

  • The initial increase in binding activity observed with the 30-kDa IGFBP is similar to that observed with IGFBP-1 in mammals in that both of these IGFBPs respond rapidly to nutritional deprivation [3].


  1. Alcohol-induced modulation of the insulin-like growth factor system in early chick embryo cranial tissue. Lynch, S.A., Elton, C.W., Carver, F.M., Pennington, S.N. Alcohol. Clin. Exp. Res. (2001) [Pubmed]
  2. Insulin-like growth factor binding protein-4 inhibits both basal and IGF-mediated chick pelvic cartilage growth in vitro. Schiltz, P.M., Mohan, S., Baylink, D.J. J. Bone Miner. Res. (1993) [Pubmed]
  3. The effects of protein restriction on insulin-like growth factor-I and IGF-binding proteins in chickens. Leili, S., Scanes, C.G. Proc. Soc. Exp. Biol. Med. (1998) [Pubmed]
  4. The effects of glucocorticoids (dexamethasone) on insulin-like growth factor-I, IGF-binding proteins, and growth in chickens. Leili, S., Scanes, C.G. Proc. Soc. Exp. Biol. Med. (1998) [Pubmed]
  5. Insulin-like growth factors and body growth in chickens divergently selected for high or low growth rate. Beccavin, C., Chevalier, B., Cogburn, L.A., Simon, J., Duclos, M.J. J. Endocrinol. (2001) [Pubmed]
  6. Identification of a single nucleotide polymorphism of the insulin-like growth factor binding protein 2 gene and its association with growth and body composition traits in the chicken. Li, Z.H., Li, H., Zhang, H., Wang, S.Z., Wang, Q.G., Wang, Y.X. J. Anim. Sci. (2006) [Pubmed]
  7. The effects of dietary restriction on insulin-like growth factor (IGF)-I and II, and IGF-binding proteins in chickens. Leili, S., Buonomo, F.C., Scanes, C.G. Proc. Soc. Exp. Biol. Med. (1997) [Pubmed]
  8. Influence of nutrition on hepatic IGF-I mRNA levels and plasma concentrations of IGF-I and IGF-II in meat-type chickens. Kita, K., Tomas, F.M., Owens, P.C., Knowles, S.E., Forbes, B.E., Upton, Z., Hughes, R., Ballard, F.J. J. Endocrinol. (1996) [Pubmed]
  9. Ontogeny of insulin-like growth factors (IGF-I and IGF-II) and IGF-binding proteins in the chicken following hatching. Radecki, S.V., Capdevielle, M.C., Buonomo, F.C., Scanes, C.G. Gen. Comp. Endocrinol. (1997) [Pubmed]
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