Disease relevance of IGFBP1

• CONCLUSIONS: The elevated IGFBP levels and reduced IGF-1 levels on days 5 and 6 of incubation are congruent with an overall reduction in the bioavailability of IGF-1 during this period and correlate with the decreased embryo weight observed in the alcohol-treated embryos [1].

High impact information on IGFBP1

• Pelvic cartilages secreted in vitro both IGF-I and IGF-II and a 32-34 kD IGFBP [2].
• In separate experiments, serum-free medium conditioned by chick pelvic cartilages for 72 h was assayed for IGF-II by radioreceptorassay, IGF-I by radioimmunoassay, and IGFBP by western ligand analysis [2].
• The decrease in circulating concentrations of IGF-I appeared to be inversely related to the initial increase in the binding activity of the 30-kDa IGFBP on Day 3 (5% and 10% protein) and to the increased binding activity of the 40-kDa IGFBP on Days 3 and 7 (10% protein) [3].
• There were no changes in circulating IGFBPs except on Day 7 when binding activity of the 36-kDa IGFBP was increased by dexamethasone (6 microg/kg) [4].
• IGFBP-28 transiently increased with fasting and was inversely related to blood glucose and insulin levels, suggesting that it is equivalent to mammalian IGFBP-1 [5].

Biological context of IGFBP1

• Identification of a single nucleotide polymorphism of the insulin-like growth factor binding protein 2 gene and its association with growth and body composition traits in the chicken [6].
• The initial increase in binding activity of the 36-kDa IGFBP may suggest that this binding protein also plays a role in the regulation and availability of circulating concentrations of IGF-I and IGF-II [7].
• IGFBP (28, 34 and 40 kDa) levels increased with age, while only faint differences were observed between genotypes [5].
• We have examined the influence of nutrition on plasma IGF-I, IGF-II and IGF-binding protein (IGFBP) levels and on hepatic IGF-I gene expression in young meat-type chickens [8].
• The major IGFBP present during much of the growth and development period was the 28-kDa form followed by the 36-kDa form [9].

Physical interactions of IGFBP1

• The 30-kDa IGFBP was most affected by feed restriction with binding activity of this IGFBP increased by 2 days of feed restriction irrespective of the degree of feed deprivation [7].

Regulatory relationships of IGFBP1

• IGF-I and IGFBP concentrations in the plasma of young broiler chickens were influenced by nutritional state but IGF-II concentrations were not [8].

Other interactions of IGFBP1

• The initial increase in binding activity observed with the 30-kDa IGFBP is similar to that observed with IGFBP-1 in mammals in that both of these IGFBPs respond rapidly to nutritional deprivation [3].

References