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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Normal intrasylvian anatomical asymmetry in children with developmental language disorder.

Symmetry of posterior intrasylvian cortices (e.g., planum temporale, planum parietale) has been suggested to represent a risk factor for developmental disorders of language and reading. Using high-resolution magnetic resonance morphometry, we studied 21 right-handed children with developmental language disorder of the phonologic-syntactic type, and found normal left-right asymmetry of the planum temporale and planum parietale when compared with 21 matched controls. The planum temporale was bilaterally smaller in the affected children, a finding accounted for by their approximately 7% smaller forebrain size. Our data do not support a role of gross visible unilateral or bilateral abnormalities of posterior intrasylvian ontogenesis in this disorder.[1]


  1. Normal intrasylvian anatomical asymmetry in children with developmental language disorder. Preis, S., Jäncke, L., Schittler, P., Huang, Y., Steinmetz, H. Neuropsychologia. (1998) [Pubmed]
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