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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Human genes for KNSL4 and MAZ are located close to one another on chromosome 16p11.2.

KNSL4 (Kid; kinesin-like DNA-binding protein) is a member of the kinesin family that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Myc-associated zinc finger protein (MAZ) participates in both the initiation and the termination of transcription of target genes. We isolated genomic DNA clones that encoded KNSL4 and MAZ from a human cosmid library. Sequence analysis revealed that the two genes were very close to one another. The distance between the two genes was only 1. 2 kb, and this intervening 1.2-kb region was extremely GC-rich. The gene for KNSL4 spanned 16 kb and consisted of 14 exons and 13 introns, while the gene for MAZ spanned 6 kb and consisted of 5 exons and 4 introns. The two genes were mapped to chromosome 16p11.2 by fluorescence in situ hybridization.[1]

References

  1. Human genes for KNSL4 and MAZ are located close to one another on chromosome 16p11.2. Song, J., Murakami, H., Yang, Z.Q., Koga, C., Adati, N., Murata, T., Geltinger, C., Saito-Ohara, F., Ikeuchi, T., Matsumura, M., Itakura, K., Kanazawa, I., Sun, K., Yokoyama, K.K. Genomics (1998) [Pubmed]
 
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