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Gene Review

KIF22  -  kinesin family member 22

Homo sapiens

Synonyms: A-328A3.2, KID, KNSL4, Kid, Kinesin-like DNA-binding protein, ...
 
 
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Disease relevance of KIF22

  • We reviewed the course of 1,076 patients with essential hypertension whose condition had been initially evaluated with both ambulatory BP (ABP) and office BP (OBP) measurements [1].
  • The Herpes simplex virus type I origin-binding protein, OBP, is encoded by the UL9 gene [2].
  • Here we use Escherichia coli exonuclease I to map the binding of the C-terminal domain of OBP to the hairpin and the helicase domains to the single-stranded tail [3].
  • By EMSA, the HHV-6B OBP DNA-binding domain was mapped to a segment containing amino acids 482 to 770 [4].
  • The OBP(H7) consensus recognition sequence of the 9-bp core, BRTYCWCCT (where B is a T, G, or C; R is a G or A; Y is a T or C; and W is a T or A), overlaps with the OBP(H6B) consensus YGWYCWCCY and establishes YCWCC as the roseolovirus OBP core recognition sequence [5].
 

Psychiatry related information on KIF22

  • The results showed that the expression patterns can vary within a subgroup of genes and that this technique is valuable for assessing which of the putative OBP genes are likely to be involved in Drosophila olfaction [6].
  • The percentage of OBP was significantly related to the degree of lung resistance during wakefulness [7].
  • The Give a Kid a Chance Omnibus Mental Health Services Act of 2003 (H.R.81) is a worthwhile proposal that endorses mental health services for children, adolescents, and their families [8].
 

High impact information on KIF22

  • This approach identified Xkid, a Xenopus homolog of human Kid (kinesin-like DNA binding protein) as a protein that is degraded in anaphase by ubiquitin-mediated proteolysis [9].
  • These experiments show that cyclinB1 is able to maintain a bipolar spindle even after sister chromatids had become separated and suggest an important role of hKid in this process [10].
  • Instead, we demonstrate here that Kid becomes active in plasmid-containing cells when plasmid copy number decreases, cleaving not only host- but also a specific plasmid-encoded mRNA at the longer and more specific target sequence UUACU [11].
  • Cdc2-mediated phosphorylation of Kid controls its distribution to spindle and chromosomes [12].
  • Kid is a kinesin-like DNA-binding protein known to be involved in chromosome movement during mitosis, although its actual motor function has not been demonstrated [13].
 

Chemical compound and disease context of KIF22

  • The aim of the present study was to compare the effects of slow-release verapamil (V), 240 mg and nitrendipine (N), 20 mg, administered once daily, on office (OBP) and 24-h ambulatory blood pressure (ABP) in patients with mild-to-moderate hypertension [14].
  • These results suggest that OBP, which is expressed at millimolar levels, might reduce HNE toxicity by removing from the nasal mucus a significant fraction of the aldehyde that is produced as a consequence of direct exposure to the oxygen present in inhaled air [15].
 

Biological context of KIF22

 

Anatomical context of KIF22

  • Moreover, the stalk region of unphosphorylated Kid interacts with microtubules and the interaction is weakened when Thr463 is phosphorylated [12].
  • Here, we performed RNA interference experiments to deplete endogenous Kid from HeLa cells and confirmed defects in metaphase chromosome arm alignment in Kid-depleted cells [18].
  • Regulatable killing of eukaryotic cells by the prokaryotic proteins Kid and Kis [19].
  • An ommochrome-binding protein (OBP) from the hemolymph of Manduca sexta has recently been purified and characterized [20].
  • The aqueous solubility of hydrophobic odorants is thought to be greatly enhanced via odorant binding proteins (OBP) which exist in the extracellular fluid surrounding the odorant receptors [21].
 

Associations of KIF22 with chemical compounds

  • Using streptavidin-coated magnetic beads, we show that OBP may bind two copies of double-stranded DNA (one biotin-labeled and the other one radioactively labeled) but only one copy of oriS*. It is the length of the single-stranded tail that determines the stoichiometry of OBP.DNA complexes [3].
  • The OBP cDNA encodes a polypeptide of 274 residues with a predicted molecular weight of 30,580 and with one consensus N-linked glycosylation site [20].
  • The sleep surfaces studied included: firm mattress covered by a sheet, Bumpa Bed, Breathe Easy, Kid Safe/Baby Air, Halo Sleep System, and Sleep Guardian [22].
  • 0. Kid pepsin contained 0.37 molecules phosphorous per molecule and was totally inhibited by 5 muM pepstatin A, being more sensitive than kid chymosin [23].
  • We purified the binding-protein of ouabain (OBP) from human plasma [24].
 

Other interactions of KIF22

 

Analytical, diagnostic and therapeutic context of KIF22

  • Indirect immunofluorescence studies show that Kid colocalizes with mitotic chromosomes and that it is enriched in the kinetochore at anaphase [27].
  • Although the longer DNA-binding domains identified by EMSA have marginal overall homology among HHV-6B and alphaherpesvirus OBP homologs, the smaller regions sufficient for the binding observed by Southwestern blotting have significant similarity [4].
  • Competitive electrophoretic mobility shift assays (EMSAs) with DNA duplexes containing single-base alterations allowed deduction of a consensus DNA sequence for HHV-6B-specific OBP binding, YGWYCWCCY, where Y is T or C and W is T or A, while that for HSV-1-specific binding was reported to be YGYTCGCACT [4].
  • Heteroduplex analysis suggests that OBP(H7) interacts along one face of the DNA helix, with the major groove, as do OBP(H6B) and herpes simplex virus type 1 OBP [5].
  • We determined the tissue-specific transcript levels of all of these OBP genes of D. melanogaster using semiquantitative RT-PCR [6].

References

  1. The prognostic value of ambulatory blood pressures. Perloff, D., Sokolow, M., Cowan, R. JAMA (1983) [Pubmed]
  2. ATP-dependent unwinding of a minimal origin of DNA replication by the origin-binding protein and the single-strand DNA-binding protein ICP8 from herpes simplex virus type I. Aslani, A., Olsson, M., Elias, P. J. Biol. Chem. (2002) [Pubmed]
  3. Functional properties of the herpes simplex virus type I origin-binding protein are controlled by precise interactions with the activated form of the origin of DNA replication. Macao, B., Olsson, M., Elias, P. J. Biol. Chem. (2004) [Pubmed]
  4. Human herpesvirus 6B origin-binding protein: DNA-binding domain and consensus binding sequence. Inoue, N., Pellett, P.E. J. Virol. (1995) [Pubmed]
  5. Sequence requirements for interaction of human herpesvirus 7 origin binding protein with the origin of lytic replication. Krug, L.T., Inoue, N., Pellett, P.E. J. Virol. (2001) [Pubmed]
  6. "Plus-C" odorant-binding protein genes in two Drosophila species and the malaria mosquito Anopheles gambiae. Zhou, J.J., Huang, W., Zhang, G.A., Pickett, J.A., Field, L.M. Gene (2004) [Pubmed]
  7. Respiration during sleep in children with COPD. Gaultier, C., Praud, J.P., Clément, A., D'Allest, A.M., Khiati, M., Tournier, G., Girard, F. Chest (1985) [Pubmed]
  8. Early childhood mental health: services that can save a life. Reasor, J.E., Farrell, S.P. Journal of pediatric nursing. (2004) [Pubmed]
  9. The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement. Funabiki, H., Murray, A.W. Cell (2000) [Pubmed]
  10. Dose-dependent effects of stable cyclin B1 on progression through mitosis in human cells. Wolf, F., Wandke, C., Isenberg, N., Geley, S. EMBO J. (2006) [Pubmed]
  11. Kid cleaves specific mRNAs at UUACU sites to rescue the copy number of plasmid R1. Pimentel, B., Madine, M.A., de la Cueva-Méndez, G. EMBO J. (2005) [Pubmed]
  12. Cdc2-mediated phosphorylation of Kid controls its distribution to spindle and chromosomes. Ohsugi, M., Tokai-Nishizumi, N., Shiroguchi, K., Toyoshima, Y.Y., Inoue, J., Yamamoto, T. EMBO J. (2003) [Pubmed]
  13. The human chromokinesin Kid is a plus end-directed microtubule-based motor. Yajima, J., Edamatsu, M., Watai-Nishii, J., Tokai-Nishizumi, N., Yamamoto, T., Toyoshima, Y.Y. EMBO J. (2003) [Pubmed]
  14. Effects of slow-release verapamil and nitrendipine on office and 24-hour ambulatory blood pressure in hypertensive patients. Pannarale, G., Puddu, P.E., Campbell, S.V., Collauto, F., Stazi, F., Reale, A. J. Cardiovasc. Pharmacol. (1992) [Pubmed]
  15. Odorant binding protein has the biochemical properties of a scavenger for 4-hydroxy-2-nonenal in mammalian nasal mucosa. Grolli, S., Merli, E., Conti, V., Scaltriti, E., Ramoni, R. FEBS J. (2006) [Pubmed]
  16. Identification, partial characterization, and genetic mapping of kinesin-like protein genes in mouse. Yang, Z., Hanlon, D.W., Marszalek, J.R., Goldstein, L.S. Genomics (1997) [Pubmed]
  17. Human genes for KNSL4 and MAZ are located close to one another on chromosome 16p11.2. Song, J., Murakami, H., Yang, Z.Q., Koga, C., Adati, N., Murata, T., Geltinger, C., Saito-Ohara, F., Ikeuchi, T., Matsumura, M., Itakura, K., Kanazawa, I., Sun, K., Yokoyama, K.K. Genomics (1998) [Pubmed]
  18. The chromokinesin Kid is required for maintenance of proper metaphase spindle size. Tokai-Nishizumi, N., Ohsugi, M., Suzuki, E., Yamamoto, T. Mol. Biol. Cell (2005) [Pubmed]
  19. Regulatable killing of eukaryotic cells by the prokaryotic proteins Kid and Kis. de la Cueva-Méndez, G., Mills, A.D., Clay-Farrace, L., Díaz-Orejas, R., Laskey, R.A. EMBO J. (2003) [Pubmed]
  20. Molecular cloning and sequence of a novel ommochrome-binding protein cDNA from an insect, Manduca sexta. Yepiz-Plascencia, G.M., Ho, C., Martel, R.R., Law, J.H. J. Biol. Chem. (1993) [Pubmed]
  21. Odorant-binding-protein subfamilies associate with distinct classes of olfactory receptor neurons in insects. Vogt, R.G., Prestwich, G.D., Lerner, M.R. J. Neurobiol. (1991) [Pubmed]
  22. Potential to prevent carbon dioxide rebreathing of commercial products marketed to reduce sudden infant death syndrome risk. Carolan, P.L., Wheeler, W.B., Ross, J.D., Kemp, R.J. Pediatrics (2000) [Pubmed]
  23. Purification and characterization of chymosin and pepsin from kid. Moschopoulou, E.E., Kandarakis, I.G., Alichanidis, E., Anifantakis, E.M. J. Dairy Res. (2006) [Pubmed]
  24. Purification and characterization of ouabain-binding protein in human plasma. Komiyama, Y., Nishimura, N., Nishino, N., Okuda, K., Munakata, M., Kosaka, C., Masuda, M., Takahashi, H. Clin. Exp. Hypertens. (1998) [Pubmed]
  25. SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis. Germani, A., Bruzzoni-Giovanelli, H., Fellous, A., Gisselbrecht, S., Varin-Blank, N., Calvo, F. Oncogene (2000) [Pubmed]
  26. The second microtubule-binding site of monomeric kid enhances the microtubule affinity. Shiroguchi, K., Ohsugi, M., Edamatsu, M., Yamamoto, T., Toyoshima, Y.Y. J. Biol. Chem. (2003) [Pubmed]
  27. Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle. Tokai, N., Fujimoto-Nishiyama, A., Toyoshima, Y., Yonemura, S., Tsukita, S., Inoue, J., Yamamota, T. EMBO J. (1996) [Pubmed]
 
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