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Gene Review

MAZ  -  MYC-associated zinc finger protein (purine...

Homo sapiens

Synonyms: MAZI, Myc-associated zinc finger protein, PUR1, Pur-1, Purine-binding transcription factor, ...
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Disease relevance of MAZ


Psychiatry related information on MAZ


High impact information on MAZ

  • In contrast, pausing of Pol II elongation induced by a high-affinity DNA-binding protein does not activate polyadenylation, indicating that G-rich MAZ sequences have a specific effect on polyadenylation [5].
  • The zinc finger protein MAZ, originally identified as a factor that binds to the c-myc P2 promoter, is associated with transcriptional termination [6].
  • Cloned MAZ was used to obtain a consensus binding site, G5AG5 [6].
  • The g11 and IgM MAZ sites lie within sequences that have activity in a termination assay and, furthermore, mutation of C2 or g11 MAZ sites severely reduces termination activity [6].
  • The MAZ consensus sequence will facilitate the identification of further sites [6].

Chemical compound and disease context of MAZ


Biological context of MAZ


Anatomical context of MAZ


Associations of MAZ with chemical compounds

  • The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1 [9].
  • FAC1, on the other hand, recognizes a conformational interface that includes the proline/alanine-rich domain of ZF87/MAZ and the first zinc finger [4].
  • Site-specific mutagenesis of MAZ revealed that the serine residue at position 480 was the major site of phosphorylation by CKII both in vitro and in vivo [10].
  • When expressed as a fusion protein in a pMAL-c vector, MAZ binds with specificity to a GA box sequence (GGGAGGG) found in the c-MYC P2 promoter, to the P2 attenuator region within the gene's first exon, and to a related sequence involved in the transcriptional termination of the C2 gene [12].
  • An S1 nuclease protection assay demonstrated the presence of multiple sites for initiation of transcription around a site 174 nucleotides (nt) upstream of the ATG codon and such expression was reflected by the promoter activity of a MAZ promoter/CAT (chloramphenicol acetyltransferase) reporter gene [13].

Physical interactions of MAZ


Regulatory relationships of MAZ

  • The data also demonstrate that control of SAF-1 activity can suppress induced expression of MMP-1 [2].
  • We therefore believe that the MAZ transcription factor is also likely to play an important role in the control of developmental expression of the CD4 gene [15].
  • Together these data indicate that SAF-1 controls cell cycle progression via p21 induction, and pathophysiological conditions that favor overexpression of SAF-1, such as an acute inflammatory condition, can trigger cellular growth arrest [3].
  • The results indicate that telomerase has been activated in the course of SAF-1 development, and the highest levels of telomerase activity correlate with an increase in cell proliferation, thus supporting a permanent cell line [16].

Other interactions of MAZ

  • Coexpression of FAC1 and ZF87/MAZ suggest that interaction of these two proteins will have biological implications for gene regulation in neurodegeneration [4].
  • The MAZ protein is an autoantigen of Hodgkin's disease and paraneoplastic cerebellar dysfunction [1].
  • The DNA-binding and transcriptional activities of MAZ, a myc-associated zinc finger protein, are regulated by casein kinase II [10].
  • Finally, ribonuclease protection assays showed that P2-specific PTHR1 mRNA transcript expression was significantly decreased in SaOS-2 cells transfected with ds-MAZ-oligo as compared with that for control (P<0.001) and ds-Sp1-oligo (P<0.05) [14].
  • Assays of DNA binding and promoter activity of three exemplary motifs (ETS, CREB, and SP1/MAZ) were used to prove the effectiveness of SPCM in uncovering active sequences [17].

Analytical, diagnostic and therapeutic context of MAZ


  1. The MAZ protein is an autoantigen of Hodgkin's disease and paraneoplastic cerebellar dysfunction. Bataller, L., Wade, D.F., Graus, F., Rosenfeld, M.R., Dalmau, J. Ann. Neurol. (2003) [Pubmed]
  2. Induction of matrix metalloproteinase 1 gene expression is regulated by inflammation-responsive transcription factor SAF-1 in osteoarthritis. Ray, A., Kuroki, K., Cook, J.L., Bal, B.S., Kenter, K., Aust, G., Ray, B.K. Arthritis Rheum. (2003) [Pubmed]
  3. Overexpression of serum amyloid A-activating factor 1 inhibits cell proliferation by the induction of cyclin-dependent protein kinase inhibitor p21WAF-1/Cip-1/Sdi-1 expression. Ray, A., Shakya, A., Kumar, D., Ray, B.K. J. Immunol. (2004) [Pubmed]
  4. Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity. Jordan-Sciutto, K.L., Dragich, J.M., Caltagarone, J., Hall, D.J., Bowser, R. Biochemistry (2000) [Pubmed]
  5. Specific transcriptional pausing activates polyadenylation in a coupled in vitro system. Yonaha, M., Proudfoot, N.J. Mol. Cell (1999) [Pubmed]
  6. MAZ-dependent termination between closely spaced human complement genes. Ashfield, R., Patel, A.J., Bossone, S.A., Brown, H., Campbell, R.D., Marcu, K.B., Proudfoot, N.J. EMBO J. (1994) [Pubmed]
  7. Selenite supplementation decreases expression of MAZ in HT29 human colon adenocarcinoma cells. Nelson, K.K., Bacon, B., Christensen, M.J. Nutrition and cancer. (1996) [Pubmed]
  8. Human genes for KNSL4 and MAZ are located close to one another on chromosome 16p11.2. Song, J., Murakami, H., Yang, Z.Q., Koga, C., Adati, N., Murata, T., Geltinger, C., Saito-Ohara, F., Ikeuchi, T., Matsumura, M., Itakura, K., Kanazawa, I., Sun, K., Yokoyama, K.K. Genomics (1998) [Pubmed]
  9. The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1. Parks, C.L., Shenk, T. J. Biol. Chem. (1996) [Pubmed]
  10. The DNA-binding and transcriptional activities of MAZ, a myc-associated zinc finger protein, are regulated by casein kinase II. Tsutsui, H., Geltinger, C., Murata, T., Itakura, K., Wada, T., Handa, H., Yokoyama, K.K. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  11. Members of the MAZ family: a novel cDNA clone for MAZ from human pancreatic islet cells. Tsutsui, H., Sakatsume, O., Itakura, K., Yokoyama, K.K. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  12. MAZ, a zinc finger protein, binds to c-MYC and C2 gene sequences regulating transcriptional initiation and termination. Bossone, S.A., Asselin, C., Patel, A.J., Marcu, K.B. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  13. Genomic organization and expression of a human gene for Myc-associated zinc finger protein (MAZ). Song, J., Murakami, H., Tsutsui, H., Tang, X., Matsumura, M., Itakura, K., Kanazawa, I., Sun, K., Yokoyama, K.K. J. Biol. Chem. (1998) [Pubmed]
  14. Functional importance of Myc-associated zinc finger protein for the human parathyroid hormone (PTH)/PTH-related peptide receptor-1 P2 promoter constitutive activity. Leroy, C., Manen, D., Rizzoli, R., Lombès, M., Silve, C. J. Mol. Endocrinol. (2004) [Pubmed]
  15. A Myc-associated zinc finger protein binding site is one of four important functional regions in the CD4 promoter. Duncan, D.D., Stupakoff, A., Hedrick, S.M., Marcu, K.B., Siu, G. Mol. Cell. Biol. (1995) [Pubmed]
  16. The piscine SAF-1 cell line: genetic stability and labeling. Béjar, J., Porta, J., Borrego, J.J., Alvarez, M.C. Mar. Biotechnol. (2005) [Pubmed]
  17. Synthetic promoter elements obtained by nucleotide sequence variation and selection for activity. Edelman, G.M., Meech, R., Owens, G.C., Jones, F.S. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  18. Interaction of Myc-associated zinc finger protein with DCC, the product of a tumor-suppressor gene, during the neural differentiation of P19 EC cells. Ugai, H., Li, H.O., Komatsu, M., Tsutsui, H., Song, J., Shiga, T., Fearon, E., Murata, T., Yokoyama, K.K. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  19. Activation of mouse RAG-2 promoter by Myc-associated zinc finger protein. Wu, C.X., Zhao, W.P., Kishi, H., Dokan, J., Jin, Z.X., Wei, X.C., Yokoyama, K.K., Muraguchi, A. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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