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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Splenic artery ligation in experimental hypersplenism.

The effects of splenic artery ligation (SAL) were examined in Sprague-Dawley rats with methyl-cellulose-induced hypersplenism. When performed close to the splenic hilium, SAL effectively reduced functioning splenic mass and raised peripheral counts of leukocytes and platelets, a response similar to that following total splenectomy. In hypersplenism, therefore, a satisfactory hematologic response may not necessary require total ablation of the spleen but merely substantial reduction of functioning splenic tissue.[1]


  1. Splenic artery ligation in experimental hypersplenism. Witte, C.L., Corrigan, J.J., Witte, M.H., O'Mara, R.E. Surgery (1976) [Pubmed]
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