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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A novel autoantibody in paraneoplastic sensory-dominant neuropathy reacts with brain-type creatine kinase.

We have previously reported on a novel autoantibody in a patient with paraneoplastic sensory-dominant neuropathy. This autoantibody immunostains the rat primary sensory system and reacts with a 47 kDa protein on immunoblotting. Here, we report on the isolation from rat spinal cord of a molecule that is recognized by this autoantibody. By ammonium sulfate cut and gel filtration, affinity and ion exchange chromatographies, the immunoreactive protein was purified to homogeneity and identified as brain-type creatine kinase ( B-CK). Our study revealed that the autoantibody of the patient reacted with B-CK in the primary sensory system.[1]

References

  1. A novel autoantibody in paraneoplastic sensory-dominant neuropathy reacts with brain-type creatine kinase. Arawaka, S., Daimon, M., Sasaki, H., Suzuki, J.I., Kato, T. Int. J. Mol. Med. (1998) [Pubmed]
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