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Chemical Compound Review

DNFB     1-fluoro-2,4-dinitro-benzene

Synonyms: DNPF, FDNB, PubChem4416, CHEMBL167423, CPD-8983, ...
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Disease relevance of Fluorodinitrobenzene


High impact information on Fluorodinitrobenzene


Chemical compound and disease context of Fluorodinitrobenzene


Biological context of Fluorodinitrobenzene


Anatomical context of Fluorodinitrobenzene


Associations of Fluorodinitrobenzene with other chemical compounds


Gene context of Fluorodinitrobenzene

  • To determine whether UVB can induce suppression in TNF-R1(-) mice, mice were irradiated on the shaved abdomen with 96 mj/cm2 UVB and 3 days later they were painted with 0.5% DNFB (sensitization dose), followed 5 days later with 0.2% DNFB to the left ear (challenge dose) [30].
  • Significant increases in IL-2 mRNA were detected in the skin after dinitrofluorobenzene challenge in normal mice, while this response was blunted in CD28 -/- mice [31].
  • Generation of contact hypersensitivity to dinitrofluorobenzene, which involves Th1 and CD8(+) effector cells, was also intact in IL-13(-/-) mice [32].
  • In contrast, following challenge with DNFB, expression of B7-2 is up-regulated in both epidermis and dermis [33].
  • Local injection of IL-1ra to sensitized BALB/c mice just before challenge with dinitrofluorobenzene resulted in a significant reduction in the intensity of CHS responses, assessed by ear swelling [34].

Analytical, diagnostic and therapeutic context of Fluorodinitrobenzene


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  22. H-2 restriction of suppressor T-cell induction by hapten-modified lymphoid cells in tolerance to 1-fluoro-2,4-dinitrobenzene contact sensitization. Miller, S.D., Sy, M.S., Claman, H.N. J. Exp. Med. (1977) [Pubmed]
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  32. IL-13 is necessary, not simply sufficient, for epicutaneously induced Th2 responses to soluble protein antigen. Herrick, C.A., Xu, L., McKenzie, A.N., Tigelaar, R.E., Bottomly, K. J. Immunol. (2003) [Pubmed]
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