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Gene Review

ABI1  -  abl-interactor 1

Homo sapiens

Synonyms: ABI-1, ABLBP4, Abelson interactor 1, Abi-1, Abl interactor 1, ...
 
 
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Disease relevance of ABI1

 

Psychiatry related information on ABI1

 

High impact information on ABI1

  • Eps8 (relative molecular mass 97,000) is a substrate of receptors with tyrosine kinase activity which binds, through its SH3 domain, to a protein designated E3b1/Abi-1 [5].
  • Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes [6].
  • Molecular genetic approaches demonstrate that Abi1 and WAVE, but not N-WASP, are essential for Rac-dependent membrane protrusion and macropinocytosis [6].
  • Abi1 interacts directly with the WHD domain of WAVE2, increases WAVE2 actin polymerization activity and mediates the assembly of a WAVE2-Abi1-Nap1-PIR121 complex [7].
  • The WAVE2-Abi1-Nap1-PIR121 complex is as active as the WAVE2-Abi1 sub-complex in stimulating Arp2/3, and after Rac activation it is re-localized to the leading edge of ruffles in vivo [7].
 

Biological context of ABI1

 

Anatomical context of ABI1

 

Associations of ABI1 with chemical compounds

  • We have identified the guanine nucleotide exchange factors Sos1 and Sos2 as novel binding partners of Abi-1 [9].
  • Interestingly, abi1-1 does not block the synergistic effect of LtWRKY21, VP1, and ABI5 co-expression, indicating that LtWRKY21, VP1, and ABI5 may form a complex that functions downstream of ABI1 to control ABA-regulated expression of genes [13].
  • It possesses a Src homology 3 (SH3) motif, proline-rich region, serine-rich region and no catalytic domain, suggesting that it seems to be a signaling protein most similar to e3B1, an eps8 SH3 binding protein [14].
 

Regulatory relationships of ABI1

 

Other interactions of ABI1

  • Our results suggest that the ABI-1 gene plays a role in leukemogenesis by translocating to MLL [10].
  • Thus, Abi1 orchestrates the proper assembly of the WAVE2 complex and mediates its activation at the leading edge in vivo [7].
  • In the present study, we used a yeast two-hybrid screen to identify Cdc2 as a novel Abi-binding protein [16].
  • Immunoprecipitation revealed that NESH (Abi-3) is present in the Abi/WAVE complex [17].
  • In addition to Abi-1, mammals possess Abi-2 and NESH (Abi-3) [17].
 

Analytical, diagnostic and therapeutic context of ABI1

References

  1. WASP-related proteins, Abi1 and Ena/VASP are required for Listeria invasion induced by the Met receptor. Bierne, H., Miki, H., Innocenti, M., Scita, G., Gertler, F.B., Takenawa, T., Cossart, P. J. Cell. Sci. (2005) [Pubmed]
  2. Human Nck-associated protein 1 and its binding protein affect the metabolism of beta-amyloid precursor protein with Swedish mutation. Yamamoto, A., Behl, C. Neurosci. Lett. (2001) [Pubmed]
  3. Is t(10;11)(p11.2;q23) involving MLL and ABI-1 genes associated with congenital acute monocytic leukemia? Morerio, C., Rosanda, C., Rapella, A., Micalizzi, C., Panarello, C. Cancer Genet. Cytogenet. (2002) [Pubmed]
  4. Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease. Yamamoto, A., Suzuki, T., Sakaki, Y. Gene (2001) [Pubmed]
  5. EPS8 and E3B1 transduce signals from Ras to Rac. Scita, G., Nordstrom, J., Carbone, R., Tenca, P., Giardina, G., Gutkind, S., Bjarnegård, M., Betsholtz, C., Di Fiore, P.P. Nature (1999) [Pubmed]
  6. Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes. Innocenti, M., Gerboth, S., Rottner, K., Lai, F.P., Hertzog, M., Stradal, T.E., Frittoli, E., Didry, D., Polo, S., Disanza, A., Benesch, S., Di Fiore, P.P., Carlier, M.F., Scita, G. Nat. Cell Biol. (2005) [Pubmed]
  7. Abi1 is essential for the formation and activation of a WAVE2 signalling complex. Innocenti, M., Zucconi, A., Disanza, A., Frittoli, E., Areces, L.B., Steffen, A., Stradal, T.E., Di Fiore, P.P., Carlier, M.F., Scita, G. Nat. Cell Biol. (2004) [Pubmed]
  8. t(10;11)-acute leukemias with MLL-AF10 and MLL-ABI1 chimeric transcripts: specific expression patterns of ABI1 gene in leukemia and solid tumor cell lines. Shibuya, N., Taki, T., Mugishima, H., Chin, M., Tsuchida, M., Sako, M., Kawa, K., Ishii, E., Miura, I., Yanagisawa, M., Hayashi, Y. Genes Chromosomes Cancer (2001) [Pubmed]
  9. Abl interactor 1 binds to sos and inhibits epidermal growth factor- and v-Abl-induced activation of extracellular signal-regulated kinases. Fan, P.D., Goff, S.P. Mol. Cell. Biol. (2000) [Pubmed]
  10. ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23). Taki, T., Shibuya, N., Taniwaki, M., Hanada, R., Morishita, K., Bessho, F., Yanagisawa, M., Hayashi, Y. Blood (1998) [Pubmed]
  11. Identification of B cell adaptor for PI3-kinase (BCAP) as an Abl interactor 1-regulated substrate of Abl kinases. Maruoka, M., Suzuki, J., Kawata, S., Yoshida, K., Hirao, N., Sato, S., Goff, S.P., Takeya, T., Tani, K., Shishido, T. FEBS Lett. (2005) [Pubmed]
  12. Regulation of actin cytoskeleton architecture by Eps8 and Abi1. Roffers-Agarwal, J., Xanthos, J.B., Miller, J.R. BMC Cell Biol. (2005) [Pubmed]
  13. A WRKY gene from creosote bush encodes an activator of the abscisic acid signaling pathway. Zou, X., Seemann, J.R., Neuman, D., Shen, Q.J. J. Biol. Chem. (2004) [Pubmed]
  14. Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein. Miyazaki, K., Matsuda, S., Ichigotani, Y., Takenouchi, Y., Hayashi, K., Fukuda, Y., Nimura, Y., Hamaguchi, M. Biochim. Biophys. Acta (2000) [Pubmed]
  15. Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation. Leng, Y., Zhang, J., Badour, K., Arpaia, E., Freeman, S., Cheung, P., Siu, M., Siminovitch, K. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  16. Abi enhances Abl-mediated CDC2 phosphorylation and inactivation. Lin, T.Y., Huang, C.H., Chou, W.G., Juang, J.L. J. Biomed. Sci. (2004) [Pubmed]
  17. NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation. Hirao, N., Sato, S., Gotoh, T., Maruoka, M., Suzuki, J., Matsuda, S., Shishido, T., Tani, K. FEBS Lett. (2006) [Pubmed]
 
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