Disease relevance of THSD3

• The Pathogenic NY-1 Hantavirus G1 Cytoplasmic Tail Inhibits RIG-I- and TBK-1-Directed Interferon Responses [1].

High impact information on THSD3

• In this study, we used the PIN*POINT (ProteIN POsition Identification with Nuclease Tail) assay to define the molecular mechanism of TR action on transcription from the thymidine kinase promoter in the cellular context [2].
• Regulation of ISW2 by Concerted Action of Histone H4 Tail and Extranucleosomal DNA [3].
• The CMP-sialic Acid Transporter Is Localized in the Medial-Trans Golgi and Possesses Two Specific Endoplasmic Reticulum Export Motifs in Its Carboxyl-terminal Cytoplasmic Tail [4].
• The increased binding was general, because it was observed in both the killer cell Ig-like receptor 2 domain long tail 1 and leukocyte Ig-like receptor-1 [5].
• A deletion mutant lacking the only tyrosine residue in tail 1 retained the polarized expression indicating that, in contrast to most basolateral sorting signals, the transport signal of the tail 1 isoform is not dependent on tyrosine [6].

Biological context of THSD3

• Further examination has shown that although the F Tail- mutant is severely debilitated in promotion of fusion as measured by using two reporter gene assays and is debilitated in the formation of syncytia relative to the wild-type F protein, the F Tail- mutant is capable of promoting the transfer of small aqueous dyes [7].
• 7. Tail currents measured after rapidly stepping the membrane potential back to the resting level consisted of a fast component associated with the closing of Ca2+ channels and a slow component that was abolished by removing Na+ [8].
• 2. Tail current analysis was used to characterize the kinetics of channel inactivation and deactivation [9].
• Results: After X-ray irradiation, persons bearing XRCC1 homozygous variant (codon 399) genotype exhibited significantly lower Tail DNA values than those bearing wild-type and heterozygous genotypes [10].
• These programmes provide a large number of measurement outcomes (i.e., tail length, %Tail DNA, various measures of tail moment, etc.) to evaluate the extent of DNA migration and DNA damage [11].

Anatomical context of THSD3

• MATERIALS AND METHODS: Flow was measured in an unstented ureter, a standard 7Fr double pigtail stent and the 7/3Fr Tail stent, 7Fr Spirastent and 14/7Fr endopyelotomy stent using a previously developed stent flow model [12].
• A dose-dependent increase in DNA damage (as assessed by % tail DNA and Olive Tail Moment) was observed in the hepatocytes of RSG-treated groups, with significant increases detected between rats treated with all the doses of RSG and the control, and between rats treated with different RSG doses (P < 0.05 - P < 0.0001) [13].
• Pen enrichment was achieved by providing a foam rubber mat on the pen wall (nose), rubber nipples (suck), a Bite-Rite Tail Chew (bite), a soil-filled tray (root), or no enrichment (control) [14].
• 4. Tail formation from the distal centriole [15].
• The ultrastructure of the spermatozoon of the drake. II. Tail [16].

Associations of THSD3 with chemical compounds

• The Transferable Tail: Fusion of the N-Terminal Acidic Extension of Heparin Cofactor II to alpha(1)-Proteinase Inhibitor M358R Specifically Increases the Rate of Thrombin Inhibition [17].
• 3. Tail artery contractions expressed as a percent of contraction to 106 mM potassium were phenylephrine (96%), moxonidine (88%), clonidine (52%), and UK14304 (30%) [18].
• Centrally Acting Imidazolines Stimulate Vascular Alpha 1A-Adrenergic Receptors in Rat-Tail Artery [18].
• Unlike human MCP which comprises many isoforms, mouse MCP cDNA predicted a single isoform of membrane MCP with cytoplasmic tail 1 (CYT1) and serine/ threonine-rich domain C (ST(C)) [19].
• Thromboxane A2 signalling in humans: a 'Tail' of two receptors [20].

Other interactions of THSD3

• We have determined the genomic organization of human TAIL1 (thrombospondin and AMOP containing isthmin-like 1), a novel isthmin-like gene encoding a protein that contains a TSR and a C-terminal AMOP domain (adhesion-associated domain in MUC4 and other proteins), characteristic of extracellular proteins involved in adhesion processes [21].

Analytical, diagnostic and therapeutic context of THSD3

• In subsequent PCR cycles, amplification is achieved using a single primer that has the same sequence as that of the Tail portion of the early cycle primers, here we refer to this as a Tag [22].
• RESULTS: In vivo the 7Fr pigtail, 14/7Fr endopyelotomy and 7/3Fr Tail stents had statistically similar flow rates [12].
• Further retrospective analysis from other in vitro and in vivo Comet assay experiments with chemical agents also suggested that OTM and %Tail DNA gave good correlation with the dose of genotoxic agents used [11].
• CONCLUSION: In this randomized, single-blind study, the 7F Tail stent produced significantly less irritative symptoms than did the standard 7F double-pigtail stent [23].
• METHODS: Tail hairs (n = 40-50) from 4 horses with known drug histories were washed, chopped into 3-5 mm fragments and extracted overnight, in 0.1 mol/l hydrochloric acid, prior to solid-phase extraction and analysis by high-performance liquid chromatography [24].

References