Gene Review:
HAS1 - hyaluronan synthase 1
Homo sapiens
Synonyms:
HA synthase 1, HAS, HuHAS1, Hyaluronan synthase 1, Hyaluronate synthase 1, ...
Spicer,
Seldin,
Olsen,
Brown,
Wells,
Doggett,
Itano,
Kimata,
Inazawa,
McDonald,
Stuhlmeier,
Pollaschek,
Recklies,
White,
Melching,
Roughley,
Stuhlmeier,
Stuhlmeier,
Pollaschek,
Yabushita,
Noguchi,
Kishida,
Fusano,
Noguchi,
Itano,
Kimata,
Noguchi,
Paiva,
Van Damme,
Tellbach,
Jones,
Jobling,
Salamonsen,
Yamada,
Itano,
Hata,
Ueda,
Kimata,
Stuhlmeier,
Yabushita,
Kishida,
Fusano,
Kanyama,
Zhuo,
Itano,
Kimata,
Noguchi,
Lokeshwar,
Selzer,
Unwala,
Estrella,
Gomez,
Golshani,
Kester,
Klumpp,
Gousse,
DeAngelis,
Oatman,
Gay,
- Hyaluronan synthase expression in pleural malignant mesotheliomas. Kanomata, N., Yokose, T., Kamijo, T., Yonou, H., Hasebe, T., Itano, N., Kimata, K., Ochiai, A. Virchows Arch. (2005)
- Role of hyaluronan and hyaluronan synthase in endometrial cancer. Yabushita, H., Kishida, T., Fusano, K., Kanyama, K., Zhuo, L., Itano, N., Kimata, K., Noguchi, M. Oncol. Rep. (2005)
- Hyaluronan synthase expression in ovarian cancer. Yabushita, H., Noguchi, M., Kishida, T., Fusano, K., Noguchi, Y., Itano, N., Kimata, K., Noguchi, M. Oncol. Rep. (2004)
- Intronic splicing of hyaluronan synthase 1 (HAS1): a biologically relevant indicator of poor outcome in multiple myeloma. Adamia, S., Reiman, T., Crainie, M., Mant, M.J., Belch, A.R., Pilarski, L.M. Blood (2005)
- Characterization of hyaluronan synthase expression and hyaluronan synthesis in bone marrow mesenchymal progenitor cells: predominant expression of HAS1 mRNA and up-regulated hyaluronan synthesis in bone marrow cells derived from multiple myeloma patients. Calabro, A., Oken, M.M., Hascall, V.C., Masellis, A.M. Blood (2002)
- Rapid chemoenzymatic synthesis of monodisperse hyaluronan oligosaccharides with immobilized enzyme reactors. DeAngelis, P.L., Oatman, L.C., Gay, D.F. J. Biol. Chem. (2003)
- Inhibition of hyaluronate synthesis. Prehm, P. Biochem. J. (1985)
- Uronate peaks and urinary hyaluronic acid levels correlate with interstitial cystitis severity. Lokeshwar, V.B., Selzer, M.G., Unwala, D.J., Estrella, V., Gomez, M.F., Golshani, R., Kester, R.R., Klumpp, D.J., Gousse, A.E. J. Urol. (2006)
- Study of hyaluronan synthase inhibitor, 4-methylumbelliferone derivatives on human pancreatic cancer cell (KP1-NL). Morohashi, H., Kon, A., Nakai, M., Yamaguchi, M., Kakizaki, I., Yoshihara, S., Sasaki, M., Takagaki, K. Biochem. Biophys. Res. Commun. (2006)
- 4-methylumbelliferone, a hyaluronan synthase suppressor, enhances the anticancer activity of gemcitabine in human pancreatic cancer cells. Nakazawa, H., Yoshihara, S., Kudo, D., Morohashi, H., Kakizaki, I., Kon, A., Takagaki, K., Sasaki, M. Cancer Chemother. Pharmacol. (2006)
- Differential effect of transforming growth factor beta (TGF-beta) on the genes encoding hyaluronan synthases and utilization of the p38 MAPK pathway in TGF-beta-induced hyaluronan synthase 1 activation. Stuhlmeier, K.M., Pollaschek, C. J. Biol. Chem. (2004)
- Differential regulation by IL-1beta and EGF of expression of three different hyaluronan synthases in oral mucosal epithelial cells and fibroblasts and dermal fibroblasts: quantitative analysis using real-time RT-PCR. Yamada, Y., Itano, N., Hata, K., Ueda, M., Kimata, K. J. Invest. Dermatol. (2004)
- Chromosomal localization of the human and mouse hyaluronan synthase genes. Spicer, A.P., Seldin, M.F., Olsen, A.S., Brown, N., Wells, D.E., Doggett, N.A., Itano, N., Kimata, K., Inazawa, J., McDonald, J.A. Genomics (1997)
- The human hyaluronan synthase genes: genomic structures, proximal promoters and polymorphic microsatellite markers. Monslow, J., Williams, J.D., Norton, N., Guy, C.A., Price, I.K., Coleman, S.L., Williams, N.M., Buckland, P.R., Spicer, A.P., Topley, N., Davies, M., Bowen, T. Int. J. Biochem. Cell Biol. (2003)
- Differential regulation and expression of hyaluronan synthases in human articular chondrocytes, synovial cells and osteosarcoma cells. Recklies, A.D., White, C., Melching, L., Roughley, P.J. Biochem. J. (2001)
- Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase. Spicer, A.P., Olson, J.S., McDonald, J.A. J. Biol. Chem. (1997)
- Abnormal expression of hyaluronan synthases in patients with Waldenstrom's macroglobulimenia. Adamia, S., Crainie, M., Kriangkum, J., Mant, M.J., Belch, A.R., Pilarski, L.M. Semin. Oncol. (2003)
- Effects of leflunomide on hyaluronan synthases (HAS): NF-kappa B-independent suppression of IL-1-induced HAS1 transcription by leflunomide. Stuhlmeier, K.M. J. Immunol. (2005)
- Glucocorticoids inhibit induced and non-induced mRNA accumulation of genes encoding hyaluronan synthases (HAS): hydrocortisone inhibits HAS1 activation by blocking the p38 mitogen-activated protein kinase signalling pathway. Stuhlmeier, K.M., Pollaschek, C. Rheumatology (Oxford, England) (2004)
- Differential regulation of hyaluronic acid synthase isoforms in human saphenous vein smooth muscle cells: possible implications for vein graft stenosis. van den Boom, M., Sarbia, M., von Wnuck Lipinski, K., Mann, P., Meyer-Kirchrath, J., Rauch, B.H., Grabitz, K., Levkau, B., Schrör, K., Fischer, J.W. Circ. Res. (2006)
- Prostaglandin E(2): A potent activator of hyaluronan synthase 1 in type-B-synoviocytes. Stuhlmeier, K.M. Biochim. Biophys. Acta (2007)
- Activation of adenosine receptor on gingival fibroblasts. Hashikawa, T., Takedachi, M., Terakura, M., Yamada, S., Thompson, L.F., Shimabukuro, Y., Murakami, S. J. Dent. Res. (2006)
- Elevated transcript level of hyaluronan synthase1 gene correlates with poor prognosis of human colon cancer. Yamada, Y., Itano, N., Narimatsu, H., Kudo, T., Morozumi, K., Hirohashi, S., Ochiai, A., Ueda, M., Kimata, K. Clin. Exp. Metastasis (2004)
- Hyaluronan synthase 3 regulates hyaluronan synthesis in cultured human keratinocytes. Sayo, T., Sugiyama, Y., Takahashi, Y., Ozawa, N., Sakai, S., Ishikawa, O., Tamura, M., Inoue, S. J. Invest. Dermatol. (2002)
- Expression of hyaluronan synthase messenger ribonucleic acids and their induction by interleukin-1beta in human orbital fibroblasts: potential insight into the molecular pathogenesis of thyroid-associated ophthalmopathy. Kaback, L.A., Smith, T.J. J. Clin. Endocrinol. Metab. (1999)
- Expression patterns of hyaluronan, hyaluronan synthases and hyaluronidases indicate a role for hyaluronan in the progression of endometrial cancer. Paiva, P., Van Damme, M.P., Tellbach, M., Jones, R.L., Jobling, T., Salamonsen, L.A. Gynecol. Oncol. (2005)