Gene Review:
HCAR2 - hydroxycarboxylic acid receptor 2
Homo sapiens
Synonyms:
G-protein coupled receptor 109A, G-protein coupled receptor HM74A, GPR109A, HCA2, HM74A, ...
Wise,
Foord,
Fraser,
Barnes,
Elshourbagy,
Eilert,
Ignar,
Murdock,
Steplewski,
Green,
Brown,
Dowell,
Szekeres,
Hassall,
Marshall,
Wilson,
Pike,
Offermanns,
Tang,
Zhou,
Gunnet,
Wines,
Cryan,
Demarest,
Zhou,
Tang,
Cryan,
Demarest,
Pike,
Maciejewski-Lenoir,
Richman,
Hakak,
Gaidarov,
Behan,
Connolly,
Karpe,
Frayn,
Carlson,
Zellner,
Pullinger,
Aouizerat,
Frost,
Kwok,
Malloy,
Kane,
- Molecular identification of high and low affinity receptors for nicotinic acid. Wise, A., Foord, S.M., Fraser, N.J., Barnes, A.A., Elshourbagy, N., Eilert, M., Ignar, D.M., Murdock, P.R., Steplewski, K., Green, A., Brown, A.J., Dowell, S.J., Szekeres, P.G., Hassall, D.G., Marshall, F.H., Wilson, S., Pike, N.B. J. Biol. Chem. (2003)
- Enhancement of arachidonic acid signaling pathway by nicotinic acid receptor HM74A. Tang, Y., Zhou, L., Gunnet, J.W., Wines, P.G., Cryan, E.V., Demarest, K.T. Biochem. Biophys. Res. Commun. (2006)
- GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing. Benyó, Z., Gille, A., Kero, J., Csiky, M., Suchánková, M.C., Nüsing, R.M., Moers, A., Pfeffer, K., Offermanns, S. J. Clin. Invest. (2005)
- Flushing out the role of GPR109A (HM74A) in the clinical efficacy of nicotinic acid. Pike, N.B. J. Clin. Invest. (2005)
- The nicotinic acid receptor GPR109A (HM74A or PUMA-G) as a new therapeutic target. Offermanns, S. Trends Pharmacol. Sci. (2006)
- Niacin therapy in atherosclerosis. Meyers, C.D., Kamanna, V.S., Kashyap, M.L. Curr. Opin. Lipidol. (2004)
- Variations in human HM74 (GPR109B) and HM74A (GPR109A) niacin receptors. Zellner, C., Pullinger, C.R., Aouizerat, B.E., Frost, P.H., Kwok, P.Y., Malloy, M.J., Kane, J.P. Hum. Mutat. (2005)
- Langerhans cells release prostaglandin D2 in response to nicotinic acid. Maciejewski-Lenoir, D., Richman, J.G., Hakak, Y., Gaidarov, I., Behan, D.P., Connolly, D.T. J. Invest. Dermatol. (2006)
- Niacin induces PPARgamma expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways. Knowles, H.J., Te Poole, R., Workman, P., Harris, A.L. Biochem. Pharmacol. (2006)
- Human epidermoid A431 cells express functional nicotinic Acid receptor HM74a. Zhou, L., Tang, Y., Cryan, E.V., Demarest, K.T. Mol. Cell. Biochem. (2007)
- The nicotinic acid receptor--a new mechanism for an old drug. Karpe, F., Frayn, K.N. Lancet (2004)
- Molecular identification of nicotinic acid receptor. Soga, T., Kamohara, M., Takasaki, J., Matsumoto, S., Saito, T., Ohishi, T., Hiyama, H., Matsuo, A., Matsushime, H., Furuichi, K. Biochem. Biophys. Res. Commun. (2003)
- Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A (HM74A/PUMA-G). Tunaru, S., Lättig, J., Kero, J., Krause, G., Offermanns, S. Mol. Pharmacol. (2005)
- Nicotinic acid receptor subtypes and their ligands. Soudijn, W., van Wijngaarden, I., Ijzerman, A.P. Med Res Rev (2007)
- Triglyceride modulation by acifran analogs: activity towards the niacin high and low affinity G protein-coupled receptors HM74A and HM74. Mahboubi, K., Witman-Jones, T., Adamus, J.E., Letsinger, J.T., Whitehouse, D., Moorman, A.R., Sawicki, D., Bergenhem, N., Ross, S.A. Biochem. Biophys. Res. Commun. (2006)
- Nicotinic acid: the broad-spectrum lipid drug. A 50th anniversary review. Carlson, L.A. J. Intern. Med. (2005)