Disease relevance of MT1L

• Three restriction fragment length polymorphisms (RFLPs), EcoRI (R), Xbal (X), and Mspl (M) of the apolipoprotein (apo)B gene, were studied to determine their distribution frequencies and influence on the lipid profiles in 148 Chinese patients with documented coronary heart disease (CHD) and in 153 healthy subjects [1].
• Thirty-nine patients with overt hypothyroidism (OH), 41 patients with mild thyroid failure (MTF), and 57 controls (CNTR) were investigated [2].
• METHODS: In 31 aneurysms, aneurysmal blood velocity was examined with digital subtraction angiography to determine mean transit time (MTF), peak density time (time to peak opacification) (PDT), and time to half-peak opacification (T1/2) [3].
• Plasma FPA levels and in vitro unstimulated MTF generation were measured simultaneously in samples obtained from 35 patients with lung cancer [4].
• In retinal diseases, abnormal temporal MTF was detected, and the curves were very similar to those of normal controls when retinal illuminance was reduced [5].

Psychiatry related information on MT1L

• We have also measured a detector MTF of 14% at 2 lp/mm, a signal of 10 pC for a 1-mR x-ray exposure at the detector entrance, a 6% nonlinearity in the detector signal over about 3 orders of magnitude in x-ray exposure, and a charge collection time (time response) of about 0.1 ms [6].
• MTF transgenders of color-African American, Latina, andAsian Pacific Islanders-experience heightened risk due to multiple stigmas associated with ethnicity and gender identity [7].

High impact information on MT1L

• At one genomic site, prolonged induction of MTF resulted in suppression of transgene silencing that persisted after withdrawal of the induction stimulus [8].
• Human monocytes generate the procoagulant tissue factor (MTF) following exposure to a variety of immune stimuli in vitro [9].
• The generation of MTF is modified by T cells, lymphokines, and immunoregulatory lipoproteins, and recent studies have shown that MTF can be activated in an immune-specific manner following exposure to antigen [9].
• Inhibition of the energy transfer by dilution of the BRET partners identified MT1R and MT2R dimers as the predominant receptor species, and this oligomerization state did not change upon agonist and antagonist binding [10].
• Agonists, neutral antagonists, and inverse agonists all promoted increases in BRET values for MT2R but not for MT1R homodimers in living cells and isolated plasma membranes [10].

Chemical compound and disease context of MT1L

• Need for HIV/AIDS Education and Intervention for MTF TransgendersResponding to the Challenge [7].

Biological context of MT1L

• A human MT gene from the functional locus on chromosome 16, MT1L, is characterised and shown to produce mRNA in at least four human tissues [11].
• The premature terminations of CML2, MT1L, and SERPINA13 genes appear to abolish the original function of the encoded protein because the mutation removes a major part of the known active site in each case [12].
• Metallothionein-1 was shown to consist of a mixture of isoforms, confirmed as metallothionein-1e, metallothionein-1g and metallothionein-1l by comparison with cDNA sequences obtained by screening a human monocyte cDNA library [13].
• One patient gave anomalous results in that although heating degraded perceptual delay and visual acuity, and depressed the sine wave grating MTF, double-flash resolution was improved [14].
• In this study, we compared the proliferation and apoptosis of mouse embryo in different culture media, including CZB, KSOM, MTF, G1.2/G2.2 sequential culture media, and in human oviductal cell coculture [15].

Anatomical context of MT1L

• Similar to MLF, Kv currents were significantly higher in sgk1+/+ mouse tail fibroblasts (MTF) [16].
• Examination of the brain and ovaries 5 h after a single sc injection of zinc chloride, administered to activate the MT1-hTGF alpha transgene, revealed that prominent sites of human TGF alpha messenger RNA expression within these tissues were the hypothalamus and ovarian follicles, respectively [17].
• Thereafter, both MTF and FTM placentas were assayed for alfentanil content (n = 3), or perfused with biophase for 1 h to determine drug washout and then assayed for alfentanil content (n = 3) [18].
• Sequential culture using G1.2/G2.2 was superior to KSOM, MTF, and CZB/CZB + G with respect to the formation of 3-4 cell embryos, morula, and blastocyst [15].
• The U937 cell line appears to be a useful in vitro model for the study of the activation of MTF [19].

Associations of MT1L with chemical compounds

• RESULTS: Exposure of RPE cells to 45 mM glucose for as short an incubation time as 6 hours resulted in a 35% decrease in MTF uptake [20].
• Alfentanil was rapidly transferred (< 5 min) across the placenta both MTF and FTM [18].
• The influence of the MTF and noise on fractal dimension estimation seriously limits the comparability of fractal dimensions estimated from radiographs which differ in noise content or MTF [21].
• Replacement treatment with levothyroxine over a period of 3 months in 12 of 39 patients with OH and in 14 of 41 patients with MTF resulted in a statistically significant decrease of oxi-LDL only in the OH group [2].
• The presampled 2D MTF of a 0.1 mm pixel pitch computed radiography system and 0.2 mm pixel pitch flat panel digital imaging system that utilized a cesium iodide scintillator was measured [22].

Analytical, diagnostic and therapeutic context of MT1L

• By assuming a rectangular slit profile with an effective width based on the kVp, HVL, and filtration material of the incident beam, an MTF correction factor was determined [23].
• Plasma circulating levels of oxi-LDL were measured by a new enzyme-linked immunosorbent assay (ELISA) kit (normal range, 40-75 mU/L) and they were found statistically significantly increased in OH compared to MTF (86 +/- 16 mU/L vs. 73 +/- 13 mU/L; p < 0.01) and to CNTR (62 +/- 11 mU/L; p < 0.001) [2].
• Maternal to fetal (MTF, n = 10) and fetal to maternal (FTM, n = 10) transfer were examined during perfusion with alfentanil 10 ng/mL, antipyrine, and creatinine for 1 h [18].
• We have measured the modulation transfer functions [MTF (f)'s] and the noise power spectra [NPS (f)] of therapy x-ray detectors irradiated by 60Co, 6- and 18-MV radiotherapy beams [24].
• On the accuracy of the computation of the PSF and the MTF of scintillation camera collimators by Fourier analysis [25].

References