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Gene Review

MEG3  -  maternally expressed 3 (non-protein coding)

Homo sapiens

Synonyms: FP504, GTL2, LINC00023, NCRNA00023, PRO0518, ...
 
 
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Disease relevance of MEG3

 

High impact information on MEG3

 

Biological context of MEG3

 

Anatomical context of MEG3

 

Associations of MEG3 with chemical compounds

 

Regulatory relationships of MEG3

  • We found that MDM2 levels were down-regulated in cells transfected with MEG3, suggesting that MDM2 suppression contributes at least in part to p53 accumulation induced by MEG3 [16].
 

Analytical, diagnostic and therapeutic context of MEG3

References

  1. A pituitary-derived MEG3 isoform functions as a growth suppressor in tumor cells. Zhang, X., Zhou, Y., Mehta, K.R., Danila, D.C., Scolavino, S., Johnson, S.R., Klibanski, A. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  2. Callipyge mutation affects gene expression in cis: a potential role for chromatin structure. Murphy, S.K., Nolan, C.M., Huang, Z., Kucera, K.S., Freking, B.A., Smith, T.P., Leymaster, K.A., Weidman, J.R., Jirtle, R.L. Genome Res. (2006) [Pubmed]
  3. Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma. Kawakami, T., Chano, T., Minami, K., Okabe, H., Okada, Y., Okamoto, K. Hum. Mol. Genet. (2006) [Pubmed]
  4. Unbalanced placental expression of imprinted genes in human intrauterine growth restriction. McMinn, J., Wei, M., Schupf, N., Cusmai, J., Johnson, E.B., Smith, A.C., Weksberg, R., Thaker, H.M., Tycko, B. Placenta (2006) [Pubmed]
  5. Selective loss of MEG3 expression and intergenic differentially methylated region hypermethylation in the MEG3/DLK1 locus in human clinically nonfunctioning pituitary adenomas. Gejman, R., Batista, D.L., Zhong, Y., Zhou, Y., Zhang, X., Swearingen, B., Stratakis, C.A., Hedley-Whyte, E.T., Klibanski, A. J. Clin. Endocrinol. Metab. (2008) [Pubmed]
  6. Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12. Lin, S.P., Youngson, N., Takada, S., Seitz, H., Reik, W., Paulsen, M., Cavaille, J., Ferguson-Smith, A.C. Nat. Genet. (2003) [Pubmed]
  7. The callipyge locus: evidence for the trans interaction of reciprocally imprinted genes. Georges, M., Charlier, C., Cockett, N. Trends Genet. (2003) [Pubmed]
  8. Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors. Zhao, J., Dahle, D., Zhou, Y., Zhang, X., Klibanski, A. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  9. Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q. Miyoshi, N., Wagatsuma, H., Wakana, S., Shiroishi, T., Nomura, M., Aisaka, K., Kohda, T., Surani, M.A., Kaneko-Ishino, T., Ishino, F. Genes Cells (2000) [Pubmed]
  10. Allele-specific methylation of a functional CTCF binding site upstream of MEG3 in the human imprinted domain of 14q32. Rosa, A.L., Wu, Y.Q., Kwabi-Addo, B., Coveler, K.J., Reid Sutton, V., Shaffer, L.G. Chromosome Res. (2005) [Pubmed]
  11. Epigenetic detection of human chromosome 14 uniparental disomy. Murphy, S.K., Wylie, A.A., Coveler, K.J., Cotter, P.D., Papenhausen, P.R., Sutton, V.R., Shaffer, L.G., Jirtle, R.L. Hum. Mutat. (2003) [Pubmed]
  12. Cyclic AMP stimulates MEG3 gene expression in cells through a cAMP-response element (CRE) in the MEG3 proximal promoter region. Zhao, J., Zhang, X., Zhou, Y., Ansell, P.J., Klibanski, A. Int. J. Biochem. Cell Biol. (2006) [Pubmed]
  13. The Testis-Specific Factor CTCFL Cooperates with the Protein Methyltransferase PRMT7 in H19 Imprinting Control Region Methylation. Jelinic, P., Stehle, J.C., Shaw, P. PLoS Biol. (2006) [Pubmed]
  14. A protein-specific monoclonal antibody to rat liver beta 1-->4 galactosyltransferase and its application to immunohistochemistry. Kawano, J., Ide, S., Oinuma, T., Suganuma, T. J. Histochem. Cytochem. (1994) [Pubmed]
  15. Conservation of genomic imprinting at the XIST, IGF2, and GTL2 loci in the bovine. Dindot, S.V., Kent, K.C., Evers, B., Loskutoff, N., Womack, J., Piedrahita, J.A. Mamm. Genome (2004) [Pubmed]
  16. Activation of p53 by MEG3 non-coding RNA. Zhou, Y., Zhong, Y., Wang, Y., Zhang, X., Batista, D.L., Gejman, R., Ansell, P.J., Zhao, J., Weng, C., Klibanski, A. J. Biol. Chem. (2007) [Pubmed]
  17. Allele-specific histone modifications regulate expression of the Dlk1-Gtl2 imprinted domain. Carr, M.S., Yevtodiyenko, A., Schmidt, C.L., Schmidt, J.V. Genomics (2007) [Pubmed]
 
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