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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Your search matched a total of 110 documents. Results 1 - 10.

Mus musculus
Gene: ... Disease relevance of Nkx2- 5 To define these pathways, we generated mice with a ventricular- restricted knockout of Nkx2- 5, which display no structural defects but have progressive complete heart block, and massive trabecular muscle overgrowth found in some patients with Nkx2- 5 mutations. In order to establish... / Synonyms: Homeobox protein Nkx-2.5; Nkx-2.5; Nkx2.5
Gallus gallus
Gene: ... High impact information on NKX2- 5 By contrast, overexpression of a human NKX2- 5 mutant did.... Differentiation of cardiac Purkinje fibers requires precise spatiotemporal regulation of Nkx2- 5 expression. Overexpression of Nkx2- 5 caused inhibition of slow tonic myosin heavy chain protein( sMHC ), a late Purkinje... / Synonyms: NKX-2.5
Rattus norvegicus
Gene: ... Disease relevance of Nkx2- 5 Interestingly, coincident with NIS expression, Nkx- 2. 5 m... that activation of GATA- 4, in cooperation with a factor binding on Nkx- 2. 5 binding element, is essential for mechanical stretch- induced cardiomyocyte hypertrophy. Functional analyses of three Csx/ Nkx- 2. 5 mutations... / Synonyms: Homeobox protein Nkx-2.5; Nkx-2.5; Nkx2.5
Homo sapiens
Gene: ... in pediatric T- ALL cell lines via a novel t( 5; 14 )( q35. 1; q32. 2). BACKGROUND: Mutations in NKX2- 5 have...- time quantitative PCR in the T- ALL case with the NKX2- 5- TRD rearrangement, 18 other cases of T- ALL...Disease relevance of NKX2- 5 Congenital heart disease caused by mutations in the transcription... / Synonyms: Homeobox protein Nkx-2.5; NKX2.5
Danio rerio
Gene: ... High impact information on nkx2. 5 Together, these results implicate zebrafish Gata5 in controlling... the expression of the early myocardial gene nkx2. 5. Forced expression of gata5 in swr/ bmp2b and Zoep mutants restores robust nkx2. 5 expression. Embryos lacking zygotic oep( Zoep mutants) display cardia bifida and... / Synonyms: nkx2-5
MeSH term: ... - mediated cytotoxicity in parallel. Postnatal conduction defects in Nkx2- 5 mutation may result at least...
Xenopus laevis
Gene: Synonyms: nkx-2.5; nkx2-5; nkx2-5b
Xenopus (Silurana) tropicalis
Gene: Synonyms: Nkx-2.5; nkx2.5
MeSH term: ... cardiac hypertrophy and heart failure that mimic human heart disease. Nkx2- 5 pathways and congenital... examined biochemical interactions of mutant Eya4 peptides. The cardiac homeobox protein Nkx2- 5 is essential in cardiac development, and mutations in Csx( which encodes Nkx2- 5) cause various congenital...
MeSH term: ... and activates the ANF gene, at least in part, by associating with the cardiac homeodomain protein Nkx2- 5. Here...


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