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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Your search matched a total of 397 documents. Results 1 - 10.

Homo sapiens
Gene: ... role of PTEN in CNS pathophysiology. Overall, our data indicate that T- ALL cells inactivate PTEN... bile ducts of mutant mice at 2 months of age and continue to grow, leading to tumor formation in all...- resistant ALL line( EU- 1) resulted in decreased cell growth and enhanced sensitivity to doxorubicin... / Synonyms: PTEN1; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Mus musculus
Gene: ... Moreover, we observe a concordant loss of Pten and EGFR overexpression in nearly all high- grade gliomas... not exhibit this mutation, and in all cases have lost the wild- type Pten allele. Thus, mTor is required...Disease relevance of Pten RESULTS: Cdx- 2 expression correlates with PTEN along the length... / Synonyms: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Drosophila melanogaster
Gene: ... Disease relevance of Pten Mesangial cell hypertrophy by high glucose is mediated by downregulation of the tumor suppressor PTEN. Hereditary mutation of PTEN causes tumor- susceptibility diseases such as Cowden..., as in mutants of the tumor suppressor PTEN. High impact information on Pten Pten is thus indispensable... / Synonyms: PTEN; PTEN3; dPTEN
Rattus norvegicus
Gene: ... Disease relevance of Pten These results suggest that alterations of the PTEN/ MMAC1 gene may not be involved in the development of adenocarcinomas induced by BHP in rats. High impact information on Pten Essential role of Pten in body size determination and pancreatic beta- cell homeostasis in vivo. Absence...
Canis lupus familiaris
Gene: ... Disease relevance of PTEN Our results document somatic point mutations or deletions encompassing the PTEN C- terminal domain in canine hemangiosarcoma that might provide cells a survival advantage within their microenvironment. High impact information on PTEN Expression of the PTEN tumor suppressor gene in malignant mammary...
Homo sapiens
Gene: ... , as an example. Chemical compound and disease context of PINK1 All sites of mutations were novel, suggesting... estimate will efficiently represent all of the common DNA variation in the entire gene. Genotyping... sequence analysis of all the coding and exon- intron junctions of the PINK1 using specific primer sets. We...
Xenopus (Silurana) tropicalis
Gene: Synonyms: pten1
MeSH term: ... - induced skin tumors, but 70% of carcinomas from Pten +/- mice do not exhibit this mutation, and in all... of chemotherapeutic treatment for all tumors; for ovarian and small- cell lung carcinomas( SCLCs ), these levels were... in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas. Chemical compound and disease...
Homo sapiens
Gene: ... pseudogene. By sequence analysis of cDNA clones, we confirmed that all the mutations including these 4 rare...Disease relevance of PTENP1 Alterations of PTEN/ MMAC1, a candidate tumor suppressor gene, and its... status and protein expression include differences in the biological effect of specific PTEN mutations... / Synonyms: PTEN-rs; PTEN2; psiPTEN
MeSH term: ... in five of five glioblastomas, all of which also showed EGFr gene overexpression, but not in well... classification and regression- tree analysis of all 174 patients identified EGFR amplification as an independent... proliferation, supporting ASPM as a potential molecular target in glioblastoma. All responsive tumors were...


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