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Gene Review

PTEN  -  phosphatase and tensin homolog

Canis lupus familiaris

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Disease relevance of PTEN

  • Our results document somatic point mutations or deletions encompassing the PTEN C-terminal domain in canine hemangiosarcoma that might provide cells a survival advantage within their microenvironment [1].

High impact information on PTEN


Biological context of PTEN

  • We examined the presence of phosphatase and tensin homolog deleted from chromosome 10 (PTEN) abnormalities that could contribute to the origin or progression of naturally occurring canine endothelial tumors (hemangiosarcoma) [1].

Anatomical context of PTEN

  • RESULTS: Compared with findings in clinically normal samples, amounts of PTEN mRNA were increased 2- to 4-fold in 4 of the 5 benign mammary gland tumor samples [2].


  1. Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma. Dickerson, E.B., Thomas, R., Fosmire, S.P., Lamerato-Kozicki, A.R., Bianco, S.R., Wojcieszyn, J.W., Breen, M., Helfand, S.C., Modiano, J.F. Vet. Pathol. (2005) [Pubmed]
  2. Expression of the PTEN tumor suppressor gene in malignant mammary gland tumors of dogs. Kanae, Y., Endoh, D., Yokota, H., Taniyama, H., Hayashi, M. Am. J. Vet. Res. (2006) [Pubmed]
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