Gene Review:
Pten - phosphatase and tensin homolog
Mus musculus
Synonyms:
2310035O07Rik, A130070J02Rik, AI463227, B430203M17Rik, MMAC1, ...
Sun,
Borowsky,
Shen,
Varmus,
Matt Karikomi,
Cardiff,
Banach-Petrosky,
Gregg,
Economides,
Desai,
Abate-Shen,
Podsypanina,
Li,
- PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway. Kim, S., Domon-Dell, C., Wang, Q., Chung, D.H., Di Cristofano, A., Pandolfi, P.P., Freund, J.N., Evers, B.M. Gastroenterology (2002)
- High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model. Wei, Q., Clarke, L., Scheidenhelm, D.K., Qian, B., Tong, A., Sabha, N., Karim, Z., Bock, N.A., Reti, R., Swoboda, R., Purev, E., Lavoie, J.F., Bajenaru, M.L., Shannon, P., Herlyn, D., Kaplan, D., Henkelman, R.M., Gutmann, D.H., Guha, A. Cancer Res. (2006)
- Evidence of a possible epigenetic inactivation mechanism operating on a region of mouse chromosome 19 in gamma-radiation-induced thymic lymphomas. Santos, J., Herranz, M., Fernández, M., Vaquero, C., López, P., Fernández-Piqueras, J. Oncogene (2001)
- Pten (phosphatase and tensin homologue gene) haploinsufficiency promotes insulin hypersensitivity. Wong, J.T., Kim, P.T., Peacock, J.W., Yau, T.Y., Mui, A.L., Chung, S.W., Sossi, V., Doudet, D., Green, D., Ruth, T.J., Parsons, R., Verchere, C.B., Ong, C.J. Diabetologia (2007)
- Allele-specific tumor spectrum in pten knockin mice. Wang, H., Karikomi, M., Naidu, S., Rajmohan, R., Caserta, E., Chen, H.Z., Rawahneh, M., Moffitt, J., Stephens, J.A., Fernandez, S.A., Weinstein, M., Wang, D., Sadee, W., La Perle, K., Stromberg, P., Rosol, T.J., Eng, C., Ostrowski, M.C., Leone, G. Proc. Natl. Acad. Sci. U. S. A. (2010)
- Murine cell lines derived from Pten null prostate cancer show the critical role of PTEN in hormone refractory prostate cancer development. Jiao, J., Wang, S., Qiao, R., Vivanco, I., Watson, P.A., Sawyers, C.L., Wu, H. Cancer Res. (2007)
- Targeted disruption of Pten in ovarian granulosa cells enhances ovulation and extends the life span of luteal cells. Fan, H.Y., Liu, Z., Cahill, N., Richards, J.S. Mol. Endocrinol. (2008)
- Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice. Ishii, H., Horie, Y., Ohshima, S., Anezaki, Y., Kinoshita, N., Dohmen, T., Kataoka, E., Sato, W., Goto, T., Sasaki, J., Sasaki, T., Watanabe, S., Suzuki, A., Ohnishi, H. J. Hepatol. (2009)
- Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse. Di Cristofano, A., De Acetis, M., Koff, A., Cordon-Cardo, C., Pandolfi, P.P. Nat. Genet. (2001)
- Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease. Kwon, C.H., Zhu, X., Zhang, J., Knoop, L.L., Tharp, R., Smeyne, R.J., Eberhart, C.G., Burger, P.C., Baker, S.J. Nat. Genet. (2001)
- Retraction: Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice. Komazawa, N., Matsuda, M., Kondoh, G., Mizunoya, W., Iwaki, M., Takagi, T., Sumikawa, Y., Inoue, K., Suzuki, A., Mak, T.W., Nakano, T., Fushiki, T., Takeda, J., Shimomura, I. Nat. Med. (2005)
- Muscle-specific Pten deletion protects against insulin resistance and diabetes. Wijesekara, N., Konrad, D., Eweida, M., Jefferies, C., Liadis, N., Giacca, A., Crackower, M., Suzuki, A., Mak, T.W., Kahn, C.R., Klip, A., Woo, M. Mol. Cell. Biol. (2005)
- Emergence of androgen independence at early stages of prostate cancer progression in nkx3.1; pten mice. Gao, H., Ouyang, X., Banach-Petrosky, W.A., Shen, M.M., Abate-Shen, C. Cancer Res. (2006)
- Transcriptional profiling endometrial carcinomas microdissected from DES-treated mice identifies changes in gene expression associated with estrogenic tumor promotion. Kabbarah, O., Mallon, M.A., Pfeifer, J.D., Goodfellow, P.J. Int. J. Cancer (2006)
- PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Sun, H., Lesche, R., Li, D.M., Liliental, J., Zhang, H., Gao, J., Gavrilova, N., Mueller, B., Liu, X., Wu, H. Proc. Natl. Acad. Sci. U.S.A. (1999)
- p18 Ink4c and Pten constrain a positive regulatory loop between cell growth and cell cycle control. Bai, F., Pei, X.H., Pandolfi, P.P., Xiong, Y. Mol. Cell. Biol. (2006)
- Akt-mediated phosphorylation and activation of estrogen receptor alpha is required for endometrial neoplastic transformation in Pten+/- mice. Vilgelm, A., Lian, Z., Wang, H., Beauparlant, S.L., Klein-Szanto, A., Ellenson, L.H., Di Cristofano, A. Cancer Res. (2006)
- Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice. Li, Y., Podsypanina, K., Liu, X., Crane, A., Tan, L.K., Parsons, R., Varmus, H.E. BMC Mol. Biol. (2001)
- Transforming acidic coiled coil 1 promotes transformation and mammary tumorigenesis. Cully, M., Shiu, J., Piekorz, R.P., Muller, W.J., Done, S.J., Mak, T.W. Cancer Res. (2005)
- Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Kurlawalla-Martinez, C., Stiles, B., Wang, Y., Devaskar, S.U., Kahn, B.B., Wu, H. Mol. Cell. Biol. (2005)
- Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases. Abate-Shen, C., Banach-Petrosky, W.A., Sun, X., Economides, K.D., Desai, N., Gregg, J.P., Borowsky, A.D., Cardiff, R.D., Shen, M.M. Cancer Res. (2003)
- In vivo magnetic resonance volumetric and spectroscopic analysis of mouse prostate cancer models. Fricke, S.T., Rodriguez, O., Vanmeter, J., Dettin, L.E., Casimiro, M., Chien, C.D., Newell, T., Johnson, K., Ileva, L., Ojeifo, J., Johnson, M.D., Albanese, C. Prostate (2006)
- Loss of a single allele of SHIP exacerbates the immunopathology of Pten heterozygous mice. Moody, J.L., Pereira, C.G., Magil, A., Fritzler, M.J., Jirik, F.R. Genes Immun. (2003)
- Hair follicle defects and squamous cell carcinoma formation in Smad4 conditional knockout mouse skin. Qiao, W., Li, A.G., Owens, P., Xu, X., Wang, X.J., Deng, C.X. Oncogene (2006)
- mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma. Hu, X., Pandolfi, P.P., Li, Y., Koutcher, J.A., Rosenblum, M., Holland, E.C. Neoplasia (2005)
- Disruption of a single Pten allele augments the chemotactic response of B lymphocytes to stromal cell-derived factor-1. Fox, J.A., Ung, K., Tanlimco, S.G., Jirik, F.R. J. Immunol. (2002)
- Vitamin d inhibits the formation of prostatic intraepithelial neoplasia in nkx3.1; pten mutant mice. Banach-Petrosky, W., Ouyang, X., Gao, H., Nader, K., Ji, Y., Suh, N., Dipaola, R.S., Abate-Shen, C. Clin. Cancer Res. (2006)
- Evolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotype. Podsypanina, K., Li, Y., Varmus, H.E. BMC medicine [electronic resource]. (2004)
- Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression. Mao, J.H., To, M.D., Perez-Losada, J., Wu, D., Del Rosario, R., Balmain, A. Genes Dev. (2004)
- mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo. Kwon, C.H., Zhu, X., Zhang, J., Baker, S.J. Proc. Natl. Acad. Sci. U.S.A. (2003)
- The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells. Kishimoto, H., Ohteki, T., Yajima, N., Kawahara, K., Natsui, M., Kawarasaki, S., Hamada, K., Horie, Y., Kubo, Y., Arase, S., Taniguchi, M., Vanhaesebroeck, B., Mak, T.W., Nakano, T., Koyasu, S., Sasaki, T., Suzuki, A. Blood (2007)
- Gene expression analysis reveals a signature of estrogen receptor activation upon loss of Pten in a mouse model of endometrial cancer. Lian, Z., De Luca, P., Di Cristofano, A. J. Cell. Physiol. (2006)
- Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo. Nguyen, K.T., Tajmir, P., Lin, C.H., Liadis, N., Zhu, X.D., Eweida, M., Tolasa-Karaman, G., Cai, F., Wang, R., Kitamura, T., Belsham, D.D., Wheeler, M.B., Suzuki, A., Mak, T.W., Woo, M. Mol. Cell. Biol. (2006)