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Gene Review:

Pten - phosphatase and tensin homolog

Rattus norvegicus

Synonyms: MMAC1, Mmac, TEP1

Tsujiuchi, T. et al., Nguyen, K.T. et al.

Tsujiuchi, Sasaki, Tsutsumi, Konishi,

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Disease relevance of Pten

These results suggest that alterations of the PTEN/MMAC1 gene may not be involved in the development of adenocarcinomas induced by BHP in rats [1].

High impact information on Pten

Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo [2].
Absence of PTEN/MMAC1 gene mutations in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats [1].
Mutations of the phosphatase and tensin homolog deleted on chromosome ten/mutated in multiple advanced cancers 1 (PTEN/MMAC1) gene were investigated in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine (BHP) in rats [1].

References

Absence of PTEN/MMAC1 gene mutations in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. Tsujiuchi, T., Sasaki, Y., Tsutsumi, M., Konishi, Y. Cancer Lett. (2001) [Pubmed]
Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo. Nguyen, K.T., Tajmir, P., Lin, C.H., Liadis, N., Zhu, X.D., Eweida, M., Tolasa-Karaman, G., Cai, F., Wang, R., Kitamura, T., Belsham, D.D., Wheeler, M.B., Suzuki, A., Mak, T.W., Woo, M. Mol. Cell. Biol. (2006) [Pubmed]

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AgaP_AGAP009628	Anopheles gambiae str. PEST
PTEN	Bos taurus
PTEN	Canis lupus familiaris
ptenb	Danio rerio
Pten	Drosophila melanogaster
PTEN	Gallus gallus
PTEN	Homo sapiens
PTEN	Macaca mulatta
Pten	Mus musculus
PTEN	Pan troglodytes
pten	Xenopus (Silurana) tropicalis

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