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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Your search matched a total of 157 documents. Results 1 - 10.

Homo sapiens
Gene: ... Disease relevance of SMAD2 Lost or very weak expression of SMAD4, SMAD2 and DCC was found in 28, 28... gene at 18q residing distal to SMAD4, SMAD2, and DCC involved in serous ovarian carcinoma. Disruption... by mutations of SMAD2 and SMAD4. Immunohistochemical evaluation of phosphorylated SMAD2/ SMAD3 and the co... / Synonyms: SMAD 2; Smad2; hSMAD2
Mus musculus
Gene: ... Disease relevance of Smad2 Compared with sham- operated kidneys, the level of Smad7 protein... Smad2 and Smad3 and renal fibrosis were inversely increased. Compound inactivation of Smad2... with adenoviruses containing dominant- negative forms of Smad2( Ad- Smad2- 3SA) and Smad3( Ad- Smad3 Delta C). Mice... / Synonyms: SMAD 2; Smad 2; Smad-2
Danio rerio
Gene: ... High impact information on smad2 PPM1A dephosphorylates and promotes nuclear export of TGFbeta- activated Smad2/ 3. Mutations in oep eliminate the response to Squint and Cyclops overexpression but are suppressed by expression of Activin and activated forms of the type I receptor ActRIB and Smad2... / Synonyms: SMAD 2; Smad2
Gallus gallus
Gene: ... High impact information on SMAD2 We also provide evidence that Gdf11 induces Smad2 phosphorylation and activated Smad2 is able to induce caudal Hox gene expression. Interestingly, the effect is specific for Smad... unaffected. The cytosolic signal transducer Smad2 is most highly expressed in chicken granulosa cells( c...
Rattus norvegicus
Gene: ... Disease relevance of Smad2 Both the degradation and ubiquitination of Smad2 were markedly increased in glomerular extracts from rats with nephritis. In this study, we investigated the expression of Smad2 and Smad3 in an in vivo animal model of lung fibrosis induced by bleomycin. Smad2 overexpression enhances... / Synonyms: SMAD 2
Chemical compound: ... the proconvertase furin through a Smad2/ 3- dependent process....
Bos taurus
Gene: ... High impact information on SMAD2 A physiological level of fluid shear stress, a known activator of endogenous MEKK- 1 activity in endothelial cells, can stimulate Smad2- mediated transcriptional activity. These effects do not require the presence of the C- terminal SSXS motif of Smad2 that is the site of TGF- beta...
Drosophila melanogaster
Gene: ... Disease relevance of Smox A missense mutation of Smad2 identified in colorectal and lung cancers... to activin and secondary axis induction by smad2. Here, we report the first identification of a novel... of Smox RESULTS: Here we report the identification of dSmad2, a new Drosophila Smad which is most related... / Synonyms: SMAD2; Smad2; dSMAD2
Xenopus (Silurana) tropicalis
Gene: Synonyms: smad-2
Ciona intestinalis


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